Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma

CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the transcriptional repressor Capicua (CIC) fused to the C-terminal transcriptional activation domain of DUX4. CDS rapidly develops resistance to...

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Detalles Bibliográficos
Autores principales: Bosnakovski, Darko, Ener, Elizabeth T., Cooper, Mark S., Gearhart, Micah D., Knights, Kevin A., Xu, Natalie C., Palumbo, Christian A., Toso, Erik A., Marsh, Graham P., Maple, Hannah J., Kyba, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511258/
https://www.ncbi.nlm.nih.gov/pubmed/34642317
http://dx.doi.org/10.1038/s41389-021-00357-4

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