Cargando…

Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase

Geminin, an inhibitor of the DNA replication licensing factor, chromatin licensing and DNA replication factor (Cdt) 1, is essential for the maintenance of genomic integrity. As a multifunctional protein, geminin is also involved in tumor progression, but the molecular details are largely unknown. He...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Haile, Gezi, Gezi, Tian, Xiaoxia, Jia, Peijun, Morigen, Morigen, Fan, Lifei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511314/ https://www.ncbi.nlm.nih.gov/pubmed/34658851 http://dx.doi.org/10.3389/fphar.2021.706240

Ejemplares similares

Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-A(Thr288)-geminin dual signaling pathways
por: Zhao, Haile, et al.
Publicado: (2022)

DnaA and LexA Proteins Regulate Transcription of the uvrB Gene in Escherichia coli: The Role of DnaA in the Control of the SOS Regulon
por: Wurihan,, et al.
Publicado: (2018)

Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1–1 plasmid
por: Yao, Yuan, et al.
Publicado: (2018)

The antihyperlipidemic drug potassium piperonate impairs the migration and tumorigenesis of breast cancer cells via the upregulation of miR-31
por: Tian, Xiaoxia, et al.
Publicado: (2022)

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis
por: Fan, Lifei, et al.
Publicado: (2017)

Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis
por: Tsunematsu, Takaaki, et al.
Publicado: (2013)

A Reduction in Ribonucleotide Reductase Activity Slows Down the Chromosome Replication Fork but Does Not Change Its Localization
por: Odsbu, Ingvild, et al.
Publicado: (2009)

The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing
por: Caillat, Christophe, et al.
Publicado: (2013)

BayesPI - a new model to study protein-DNA interactions: a case study of condition-specific protein binding parameters for Yeast transcription factors
por: Wang, Junbai, et al.
Publicado: (2009)

A Spatial Control for Correct Timing of Gene Expression during the Escherichia coli Cell Cycle
por: Yao, Yuan, et al.
Publicado: (2016)

Preferential Re-Replication of Drosophila Heterochromatin in the Absence of Geminin
por: Ding, Queying, et al.
Publicado: (2010)

Spotlight on Geminin
por: DePamphilis, Melvin L
Publicado: (2011)

Geminin halts DNA synthesis
por: LeBrasseur, Nicole
Publicado: (2004)

Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells
por: Karantzelis, Nikolaos, et al.
Publicado: (2022)

AspC-Mediated Aspartate Metabolism Coordinates the Escherichia coli Cell Cycle
por: Liu, Feng, et al.
Publicado: (2014)

Evaluation of Novel Antibacterial N-Halamine Nanoparticles Prodrugs towards Susceptibility of Escherichia coli Induced by DksA Protein
por: Dong, Qigeqi, et al.
Publicado: (2015)

Editorial: Bacterial Transcription Factors and the Cell Cycle
por: Morigen,, et al.
Publicado: (2021)

Geminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility
por: YUAN, Yue, et al.
Publicado: (2017)

Blimp-1 Upregulation by Multiple Ligands via EGFR Transactivation Inhibits Cell Migration in Keratinocytes and Squamous Cell Carcinoma
por: Lee, Hyemin, et al.
Publicado: (2022)

Geminin Inhibits a Late Step in the Formation of Human Pre-replicative Complexes
por: Wu, Min, et al.
Publicado: (2014)

Geminin Is Required for the Maintenance of Pluripotency
por: Tabrizi, Golnaz A., et al.
Publicado: (2013)

Targeting PAR2 Overcomes Gefitinib Resistance in Non-Small-Cell Lung Cancer Cells Through Inhibition of EGFR Transactivation
por: Jiang, Yuhong, et al.
Publicado: (2021)

Cervical neuroendocrine carcinoma in the third trimester: a rare case report and literature review
por: Chen, Gezi, et al.
Publicado: (2023)

Trimethylamine N-Oxide Reduces the Susceptibility of Escherichia coli to Multiple Antibiotics
por: Qiao, Jiaxin, et al.
Publicado: (2022)

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
por: Ma, Jian, et al.
Publicado: (2021)

Predictive Factors for Recovery Time in Conceived Women Suffering From Moderate to Severe Ovarian Hyperstimulation Syndrome
por: Huang, Kai, et al.
Publicado: (2022)

Editorial: Bacterial transcription factors and the cell cycle, volume II
por: Morigen, et al.
Publicado: (2023)

An Inactive Geminin Mutant That Binds Cdt1
por: Suchyta, Marissa, et al.
Publicado: (2015)

Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions
por: Choi, Sun-Hye, et al.
Publicado: (2015)

EGFR transactivates RON to drive oncogenic crosstalk
por: Franco Nitta, Carolina, et al.
Publicado: (2021)

Management of intra-operative acute pulmonary embolism during general anesthesia: a case report
por: Mao, Yuanyuan, et al.
Publicado: (2017)

At the deep end: COVID-19 experiences of Zimbabwean health and care workers in the United Kingdom
por: Mbiba, Beacon, et al.
Publicado: (2020)

Acacetin exerts antitumor effects on gastric cancer by targeting EGFR
por: Zhang, Guangtao, et al.
Publicado: (2023)

The study on the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of nerve root sciatica: A protocol for systematic review and meta-analysis of randomized controlled trials
por: Han, Zhaoyi, et al.
Publicado: (2021)

Rapamycin Induces Transactivation of the EGFR and Increases Cell Survival
por: Chaturvedi, Deepti, et al.
Publicado: (2009)

EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis
por: Yang, Xiao-Pei, et al.
Publicado: (2016)

Enhancement of P2X3 Receptor-Mediated Currents by Lysophosphatidic Acid in Rat Primary Sensory Neurons
por: Qiao, Wen-Long, et al.
Publicado: (2022)

In vitro pharmacological characterization of standard and new lysophosphatidic acid receptor antagonists using dynamic mass redistribution assay
por: Ruzza, C., et al.
Publicado: (2023)

Loss of Geminin induces rereplication in the presence of functional p53
por: Melixetian, Marina, et al.
Publicado: (2004)

Geminin overexpression induces mammary tumors via suppressing cytokinesis
por: Blanchard, Zannel, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_udhl1luusetgfm2gsrte3vtj8g