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mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence

Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5) might be efficacious in treati...

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Detalles Bibliográficos
Autores principales:	Stoppel, David C., McCamphill, Patrick K., Senter, Rebecca K., Heynen, Arnold J., Bear, Mark F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511445/ https://www.ncbi.nlm.nih.gov/pubmed/34658956 http://dx.doi.org/10.3389/fpsyt.2021.718953

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