Panobinostat Effectively Increases Histone Acetylation and Alters Chromatin Accessibility Landscape in Canine Embryonic Fibroblasts but Does Not Enhance Cellular Reprogramming

Robust and reproducible protocols to efficiently reprogram adult canine cells to induced pluripotent stem cells are still elusive. Somatic cell reprogramming requires global chromatin remodeling that is finely orchestrated spatially and temporally. Histone acetylation and deacetylation are key regul...

Descripción completa

Detalles Bibliográficos
Autores principales: Moshref, Maryam, Questa, Maria, Lopez-Cervantes, Veronica, Sears, Thomas K., Greathouse, Rachel L., Crawford, Charles K., Kol, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511502/
https://www.ncbi.nlm.nih.gov/pubmed/34660761
http://dx.doi.org/10.3389/fvets.2021.716570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511502/
https://www.ncbi.nlm.nih.gov/pubmed/34660761
http://dx.doi.org/10.3389/fvets.2021.716570

Ejemplares similares