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COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review

Subacute thyroiditis (SAT) is a thyroid disease of viral or post-viral origin. Whether SAT represents a complication of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still unclear. Our aim was to systematically review the literature to...

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Autores principales: Trimboli, Pierpaolo, Cappelli, Carlo, Croce, Laura, Scappaticcio, Lorenzo, Chiovato, Luca, Rotondi, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511511/
https://www.ncbi.nlm.nih.gov/pubmed/34659109
http://dx.doi.org/10.3389/fendo.2021.707726
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author Trimboli, Pierpaolo
Cappelli, Carlo
Croce, Laura
Scappaticcio, Lorenzo
Chiovato, Luca
Rotondi, Mario
author_facet Trimboli, Pierpaolo
Cappelli, Carlo
Croce, Laura
Scappaticcio, Lorenzo
Chiovato, Luca
Rotondi, Mario
author_sort Trimboli, Pierpaolo
collection PubMed
description Subacute thyroiditis (SAT) is a thyroid disease of viral or post-viral origin. Whether SAT represents a complication of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still unclear. Our aim was to systematically review the literature to 1) explore the size of the literature about SAT in COVID-19 and 2) evaluate the clinical characteristics of SAT. PubMed/MEDLINE, Embase, and Scopus were searched until April 20, 2021. Original papers, case reports, and case series reporting SAT in COVID-19 patients were included. Authors and their country, journal, year of publication, COVID-19 and SAT clinical presentation, thyroid function, therapy, and follow-up data were extracted. Nineteen papers (17 case reports and 2 case series) were included, describing 27 patients, 74.1% females, aged 18 to 69 years. COVID-19 was diagnosed by nasopharyngeal swab in 66.7% cases and required hospitalization in 11.1%. In 83.3% cases, SAT occurred after COVID-19. Neck pain was present in 92.6% cases and fever in 74.1%. Median TSH, fT3, and fT4 were 0.01 mU/l, 10.79 pmol/l, and 27.2 pmol/l, respectively. C-reactive-protein and erythrocyte sedimentation rate were elevated in 96% of cases. Typical ultrasonographic characteristics of SAT were observed in 83.3% of cases. Steroids were the most frequent SAT therapy. Complete remission of SAT was recorded in most cases. In conclusion, the size and quality of published data of SAT in COVID-19 patients are poor, with only case reports and case series being available. SAT clinical presentation in COVID-19 patients seems to be similar to what is generally expected.
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spelling pubmed-85115112021-10-14 COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review Trimboli, Pierpaolo Cappelli, Carlo Croce, Laura Scappaticcio, Lorenzo Chiovato, Luca Rotondi, Mario Front Endocrinol (Lausanne) Endocrinology Subacute thyroiditis (SAT) is a thyroid disease of viral or post-viral origin. Whether SAT represents a complication of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still unclear. Our aim was to systematically review the literature to 1) explore the size of the literature about SAT in COVID-19 and 2) evaluate the clinical characteristics of SAT. PubMed/MEDLINE, Embase, and Scopus were searched until April 20, 2021. Original papers, case reports, and case series reporting SAT in COVID-19 patients were included. Authors and their country, journal, year of publication, COVID-19 and SAT clinical presentation, thyroid function, therapy, and follow-up data were extracted. Nineteen papers (17 case reports and 2 case series) were included, describing 27 patients, 74.1% females, aged 18 to 69 years. COVID-19 was diagnosed by nasopharyngeal swab in 66.7% cases and required hospitalization in 11.1%. In 83.3% cases, SAT occurred after COVID-19. Neck pain was present in 92.6% cases and fever in 74.1%. Median TSH, fT3, and fT4 were 0.01 mU/l, 10.79 pmol/l, and 27.2 pmol/l, respectively. C-reactive-protein and erythrocyte sedimentation rate were elevated in 96% of cases. Typical ultrasonographic characteristics of SAT were observed in 83.3% of cases. Steroids were the most frequent SAT therapy. Complete remission of SAT was recorded in most cases. In conclusion, the size and quality of published data of SAT in COVID-19 patients are poor, with only case reports and case series being available. SAT clinical presentation in COVID-19 patients seems to be similar to what is generally expected. Frontiers Media S.A. 2021-09-29 /pmc/articles/PMC8511511/ /pubmed/34659109 http://dx.doi.org/10.3389/fendo.2021.707726 Text en Copyright © 2021 Trimboli, Cappelli, Croce, Scappaticcio, Chiovato and Rotondi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Trimboli, Pierpaolo
Cappelli, Carlo
Croce, Laura
Scappaticcio, Lorenzo
Chiovato, Luca
Rotondi, Mario
COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review
title COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review
title_full COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review
title_fullStr COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review
title_full_unstemmed COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review
title_short COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review
title_sort covid-19-associated subacute thyroiditis: evidence-based data from a systematic review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511511/
https://www.ncbi.nlm.nih.gov/pubmed/34659109
http://dx.doi.org/10.3389/fendo.2021.707726
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