Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections

The efficacy of dupilumab in pediatric patients with severe eczema presenting in the setting of elevated immunoglobulin E (IgE) levels and recurrent bacterial skin infections is not well-understood. Here we present the case of a child with elevated IgE levels in whom dupilumab treatment led to remar...

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Autores principales: Joshi, Tejas P., Anvari, Sara, Gupta, Meera R., Davis, Carla M., Hajjar, Joud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511520/
https://www.ncbi.nlm.nih.gov/pubmed/34660469
http://dx.doi.org/10.3389/fped.2021.646997
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author Joshi, Tejas P.
Anvari, Sara
Gupta, Meera R.
Davis, Carla M.
Hajjar, Joud
author_facet Joshi, Tejas P.
Anvari, Sara
Gupta, Meera R.
Davis, Carla M.
Hajjar, Joud
author_sort Joshi, Tejas P.
collection PubMed
description The efficacy of dupilumab in pediatric patients with severe eczema presenting in the setting of elevated immunoglobulin E (IgE) levels and recurrent bacterial skin infections is not well-understood. Here we present the case of a child with elevated IgE levels in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with molecularly proven cases of hyper IgE (HIGE) syndrome. Our case supports the notion that dupilumab may have a seminal application in treating severe eczema that occurs in the setting of elevated IgE levels and recurrent bacterial skin infections.
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spelling pubmed-85115202021-10-14 Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections Joshi, Tejas P. Anvari, Sara Gupta, Meera R. Davis, Carla M. Hajjar, Joud Front Pediatr Pediatrics The efficacy of dupilumab in pediatric patients with severe eczema presenting in the setting of elevated immunoglobulin E (IgE) levels and recurrent bacterial skin infections is not well-understood. Here we present the case of a child with elevated IgE levels in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with molecularly proven cases of hyper IgE (HIGE) syndrome. Our case supports the notion that dupilumab may have a seminal application in treating severe eczema that occurs in the setting of elevated IgE levels and recurrent bacterial skin infections. Frontiers Media S.A. 2021-09-29 /pmc/articles/PMC8511520/ /pubmed/34660469 http://dx.doi.org/10.3389/fped.2021.646997 Text en Copyright © 2021 Joshi, Anvari, Gupta, Davis and Hajjar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Joshi, Tejas P.
Anvari, Sara
Gupta, Meera R.
Davis, Carla M.
Hajjar, Joud
Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections
title Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections
title_full Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections
title_fullStr Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections
title_full_unstemmed Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections
title_short Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections
title_sort case report: dupilumab successfully controls severe eczema in a child with elevated ige levels and recurrent skin infections
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511520/
https://www.ncbi.nlm.nih.gov/pubmed/34660469
http://dx.doi.org/10.3389/fped.2021.646997
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