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DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury

Acute peripheral nerve injury can lead to chronic neuropathic pain. Having a standardized, non-invasive method to evaluate pathological changes in a nerve following nerve injury would help with diagnostic and therapeutic assessments or interventions. The accurate evaluation of nerve fiber integrity...

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Autores principales: Holmes, Scott A., Karapanagou, Anastasia, Staffa, Steven J., Zurakowski, David, Borra, Ronald, Simons, Laura E., Sieberg, Christine, Lebel, Alyssa, Borsook, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511521/
https://www.ncbi.nlm.nih.gov/pubmed/34660471
http://dx.doi.org/10.3389/fped.2021.656843
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author Holmes, Scott A.
Karapanagou, Anastasia
Staffa, Steven J.
Zurakowski, David
Borra, Ronald
Simons, Laura E.
Sieberg, Christine
Lebel, Alyssa
Borsook, David
author_facet Holmes, Scott A.
Karapanagou, Anastasia
Staffa, Steven J.
Zurakowski, David
Borra, Ronald
Simons, Laura E.
Sieberg, Christine
Lebel, Alyssa
Borsook, David
author_sort Holmes, Scott A.
collection PubMed
description Acute peripheral nerve injury can lead to chronic neuropathic pain. Having a standardized, non-invasive method to evaluate pathological changes in a nerve following nerve injury would help with diagnostic and therapeutic assessments or interventions. The accurate evaluation of nerve fiber integrity after injury may provide insight into the extent of pathology and a patient's level of self-reported pain. The aim of this investigation was to evaluate the extent to which peripheral nerve integrity could be evaluated in an acute ankle injury cohort and how markers of nerve fiber integrity correlate with self-reported pain levels in afferent nerves. We recruited 39 pediatric participants with clinically defined neuropathic pain within 3 months of an ankle injury and 16 healthy controls. Participants underwent peripheral nerve MRI using diffusion tensor (DTI) and magnetization transfer imaging (MTI) of their injured and non-injured ankles. The imaging window was focused on the branching point of the sciatic nerve into the tibial and fibular division. Each participant completed the Pain Detection Questionnaire (PDQ). Findings demonstrated group differences in DTI and MTI in the sciatic, tibial and fibular nerve in the injured ankle relative to healthy control and contralateral non-injured nerve fibers. Only AD and RD from the injured fibular nerve correlated with PDQ scores which coincides with the inversion-dominant nature of this particular ankle injuruy cohort. Exploratory analyses highlight the potential remodeling stages of nerve injury from neuropathic pain. Future research should emphasize sub-acute time frames of injury to capture post-injury inflammation and nerve fiber recovery.
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spelling pubmed-85115212021-10-14 DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury Holmes, Scott A. Karapanagou, Anastasia Staffa, Steven J. Zurakowski, David Borra, Ronald Simons, Laura E. Sieberg, Christine Lebel, Alyssa Borsook, David Front Pediatr Pediatrics Acute peripheral nerve injury can lead to chronic neuropathic pain. Having a standardized, non-invasive method to evaluate pathological changes in a nerve following nerve injury would help with diagnostic and therapeutic assessments or interventions. The accurate evaluation of nerve fiber integrity after injury may provide insight into the extent of pathology and a patient's level of self-reported pain. The aim of this investigation was to evaluate the extent to which peripheral nerve integrity could be evaluated in an acute ankle injury cohort and how markers of nerve fiber integrity correlate with self-reported pain levels in afferent nerves. We recruited 39 pediatric participants with clinically defined neuropathic pain within 3 months of an ankle injury and 16 healthy controls. Participants underwent peripheral nerve MRI using diffusion tensor (DTI) and magnetization transfer imaging (MTI) of their injured and non-injured ankles. The imaging window was focused on the branching point of the sciatic nerve into the tibial and fibular division. Each participant completed the Pain Detection Questionnaire (PDQ). Findings demonstrated group differences in DTI and MTI in the sciatic, tibial and fibular nerve in the injured ankle relative to healthy control and contralateral non-injured nerve fibers. Only AD and RD from the injured fibular nerve correlated with PDQ scores which coincides with the inversion-dominant nature of this particular ankle injuruy cohort. Exploratory analyses highlight the potential remodeling stages of nerve injury from neuropathic pain. Future research should emphasize sub-acute time frames of injury to capture post-injury inflammation and nerve fiber recovery. Frontiers Media S.A. 2021-09-29 /pmc/articles/PMC8511521/ /pubmed/34660471 http://dx.doi.org/10.3389/fped.2021.656843 Text en Copyright © 2021 Holmes, Karapanagou, Staffa, Zurakowski, Borra, Simons, Sieberg, Lebel and Borsook. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Holmes, Scott A.
Karapanagou, Anastasia
Staffa, Steven J.
Zurakowski, David
Borra, Ronald
Simons, Laura E.
Sieberg, Christine
Lebel, Alyssa
Borsook, David
DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury
title DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury
title_full DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury
title_fullStr DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury
title_full_unstemmed DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury
title_short DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury
title_sort dti and mtr measures of nerve fiber integrity in pediatric patients with ankle injury
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511521/
https://www.ncbi.nlm.nih.gov/pubmed/34660471
http://dx.doi.org/10.3389/fped.2021.656843
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