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Endoplasmic Reticulum Quality Control in Immune Cells
The endoplasmic reticulum quality control (ERQC) system, including endoplasmic reticulum-associated degradation (ERAD), the unfolded protein response (UPR), and autophagy, presides over cellular protein secretion and maintains proteostasis in mammalian cells. As part of the immune system, a variety...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511527/ https://www.ncbi.nlm.nih.gov/pubmed/34660599 http://dx.doi.org/10.3389/fcell.2021.740653 |
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author | Jiang, Yalan Tao, Zehua Chen, Hua Xia, Sheng |
author_facet | Jiang, Yalan Tao, Zehua Chen, Hua Xia, Sheng |
author_sort | Jiang, Yalan |
collection | PubMed |
description | The endoplasmic reticulum quality control (ERQC) system, including endoplasmic reticulum-associated degradation (ERAD), the unfolded protein response (UPR), and autophagy, presides over cellular protein secretion and maintains proteostasis in mammalian cells. As part of the immune system, a variety of proteins are synthesized and assembled correctly for the development, activation, and differentiation of immune cells, such as dendritic cells (DCs), macrophages, myeloid-derived-suppressor cells (MDSCs), B lymphocytes, T lymphocytes, and natural killer (NK) cells. In this review, we emphasize the role of the ERQC in these immune cells, and also discuss how the imbalance of ER homeostasis affects the immune response, thereby suggesting new therapeutic targets for immunotherapy. |
format | Online Article Text |
id | pubmed-8511527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85115272021-10-14 Endoplasmic Reticulum Quality Control in Immune Cells Jiang, Yalan Tao, Zehua Chen, Hua Xia, Sheng Front Cell Dev Biol Cell and Developmental Biology The endoplasmic reticulum quality control (ERQC) system, including endoplasmic reticulum-associated degradation (ERAD), the unfolded protein response (UPR), and autophagy, presides over cellular protein secretion and maintains proteostasis in mammalian cells. As part of the immune system, a variety of proteins are synthesized and assembled correctly for the development, activation, and differentiation of immune cells, such as dendritic cells (DCs), macrophages, myeloid-derived-suppressor cells (MDSCs), B lymphocytes, T lymphocytes, and natural killer (NK) cells. In this review, we emphasize the role of the ERQC in these immune cells, and also discuss how the imbalance of ER homeostasis affects the immune response, thereby suggesting new therapeutic targets for immunotherapy. Frontiers Media S.A. 2021-09-29 /pmc/articles/PMC8511527/ /pubmed/34660599 http://dx.doi.org/10.3389/fcell.2021.740653 Text en Copyright © 2021 Jiang, Tao, Chen and Xia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Jiang, Yalan Tao, Zehua Chen, Hua Xia, Sheng Endoplasmic Reticulum Quality Control in Immune Cells |
title | Endoplasmic Reticulum Quality Control in Immune Cells |
title_full | Endoplasmic Reticulum Quality Control in Immune Cells |
title_fullStr | Endoplasmic Reticulum Quality Control in Immune Cells |
title_full_unstemmed | Endoplasmic Reticulum Quality Control in Immune Cells |
title_short | Endoplasmic Reticulum Quality Control in Immune Cells |
title_sort | endoplasmic reticulum quality control in immune cells |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511527/ https://www.ncbi.nlm.nih.gov/pubmed/34660599 http://dx.doi.org/10.3389/fcell.2021.740653 |
work_keys_str_mv | AT jiangyalan endoplasmicreticulumqualitycontrolinimmunecells AT taozehua endoplasmicreticulumqualitycontrolinimmunecells AT chenhua endoplasmicreticulumqualitycontrolinimmunecells AT xiasheng endoplasmicreticulumqualitycontrolinimmunecells |