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Primary epithelioid hemangioendothelioma of the penis: a case report and literature review
Epithelioid hemangioendothelioma (EHE) is a rare vascular tumour with an intermediate behaviour between benign hemangioma and malignant angiosarcoma. There is scarce data on the penile EHE’s management and its natural history, as our knowledge is based on few reported cases with a short follow-up pe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511538/ https://www.ncbi.nlm.nih.gov/pubmed/34733664 http://dx.doi.org/10.21037/tau-21-277 |
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author | Artiles Medina, Alberto Fraile Poblador, Agustín Hevia Palacios, Manuel Carretero Barrio, Irene Reguero, María Eugenia Rodríguez-Patrón Rodríguez, Rafael Burgos Revilla, Francisco Javier |
author_facet | Artiles Medina, Alberto Fraile Poblador, Agustín Hevia Palacios, Manuel Carretero Barrio, Irene Reguero, María Eugenia Rodríguez-Patrón Rodríguez, Rafael Burgos Revilla, Francisco Javier |
author_sort | Artiles Medina, Alberto |
collection | PubMed |
description | Epithelioid hemangioendothelioma (EHE) is a rare vascular tumour with an intermediate behaviour between benign hemangioma and malignant angiosarcoma. There is scarce data on the penile EHE’s management and its natural history, as our knowledge is based on few reported cases with a short follow-up period. We present a case report and conducted a literature review, including 17 cases. The relevance of this case report derives from the need for better clinical characterization of patients with penile EHE and the importance of defining the outcomes. We report the case of a 53-year-old male with a 1-year history of sleep-related painful erections. Imaging techniques showed a well-defined hypoechoic and hypervascular solid nodule on the dorsal aspect of the penis. It was surgically removed, and the histopathological study revealed a low-risk EHE of the penis. Follow-up magnetic resonance imaging (MRI) and computed tomography did not demonstrate local recurrence nor metastases. According to the literature review, most of the patients were in their fifth and sixth decades of life at the time of diagnosis and lesions were usually located in the glans. The most common clinical presentation was as a painful mass. Follow-up period ranged from 2 months to 5 years. Three patients showed systemic metastases, two of which died due to cancer. The conclusions from the literature review are limited by the reduced number of cases and the short follow-up. This case report highlights the importance of understanding the diagnosis and treatment of this type of rare non-squamous malignant tumours of the penis. Penile EHE is a malignant vascular tumour that is very rare in this location. The best treatment is local excision, with re-excision or intraoperative margins assessment. Occasionally, systemic chemotherapy and radiation therapy can be useful. There is consensus on the importance of very strict follow-up of these patients. |
format | Online Article Text |
id | pubmed-8511538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-85115382021-11-02 Primary epithelioid hemangioendothelioma of the penis: a case report and literature review Artiles Medina, Alberto Fraile Poblador, Agustín Hevia Palacios, Manuel Carretero Barrio, Irene Reguero, María Eugenia Rodríguez-Patrón Rodríguez, Rafael Burgos Revilla, Francisco Javier Transl Androl Urol Case Report Epithelioid hemangioendothelioma (EHE) is a rare vascular tumour with an intermediate behaviour between benign hemangioma and malignant angiosarcoma. There is scarce data on the penile EHE’s management and its natural history, as our knowledge is based on few reported cases with a short follow-up period. We present a case report and conducted a literature review, including 17 cases. The relevance of this case report derives from the need for better clinical characterization of patients with penile EHE and the importance of defining the outcomes. We report the case of a 53-year-old male with a 1-year history of sleep-related painful erections. Imaging techniques showed a well-defined hypoechoic and hypervascular solid nodule on the dorsal aspect of the penis. It was surgically removed, and the histopathological study revealed a low-risk EHE of the penis. Follow-up magnetic resonance imaging (MRI) and computed tomography did not demonstrate local recurrence nor metastases. According to the literature review, most of the patients were in their fifth and sixth decades of life at the time of diagnosis and lesions were usually located in the glans. The most common clinical presentation was as a painful mass. Follow-up period ranged from 2 months to 5 years. Three patients showed systemic metastases, two of which died due to cancer. The conclusions from the literature review are limited by the reduced number of cases and the short follow-up. This case report highlights the importance of understanding the diagnosis and treatment of this type of rare non-squamous malignant tumours of the penis. Penile EHE is a malignant vascular tumour that is very rare in this location. The best treatment is local excision, with re-excision or intraoperative margins assessment. Occasionally, systemic chemotherapy and radiation therapy can be useful. There is consensus on the importance of very strict follow-up of these patients. AME Publishing Company 2021-09 /pmc/articles/PMC8511538/ /pubmed/34733664 http://dx.doi.org/10.21037/tau-21-277 Text en 2021 Translational Andrology and Urology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Case Report Artiles Medina, Alberto Fraile Poblador, Agustín Hevia Palacios, Manuel Carretero Barrio, Irene Reguero, María Eugenia Rodríguez-Patrón Rodríguez, Rafael Burgos Revilla, Francisco Javier Primary epithelioid hemangioendothelioma of the penis: a case report and literature review |
title | Primary epithelioid hemangioendothelioma of the penis: a case report and literature review |
title_full | Primary epithelioid hemangioendothelioma of the penis: a case report and literature review |
title_fullStr | Primary epithelioid hemangioendothelioma of the penis: a case report and literature review |
title_full_unstemmed | Primary epithelioid hemangioendothelioma of the penis: a case report and literature review |
title_short | Primary epithelioid hemangioendothelioma of the penis: a case report and literature review |
title_sort | primary epithelioid hemangioendothelioma of the penis: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511538/ https://www.ncbi.nlm.nih.gov/pubmed/34733664 http://dx.doi.org/10.21037/tau-21-277 |
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