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Survival-Weighted Health Profiles in Patients Treated for Advanced Oral Cavity Squamous Cell Carcinoma

OBJECTIVES: For patients with oral cavity squamous cell carcinoma (OSCC), particularly for those with advanced disease, quality of life (QoL) is a key outcome measure. Therefore, we estimated survival-weighted psychometric scores (SWPS), life expectancy (LE), and quality-adjusted LE (QALE) in patien...

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Autores principales: Tsai, Yao-Te, Chen, Wen-Cheng, Hsu, Cheng-Ming, Tsai, Ming-Shao, Chang, Geng-He, Lee, Yi-Chan, Huang, Ethan I., Fang, Chiung-Cheng, Lai, Chia-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511634/
https://www.ncbi.nlm.nih.gov/pubmed/34660322
http://dx.doi.org/10.3389/fonc.2021.754412
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author Tsai, Yao-Te
Chen, Wen-Cheng
Hsu, Cheng-Ming
Tsai, Ming-Shao
Chang, Geng-He
Lee, Yi-Chan
Huang, Ethan I.
Fang, Chiung-Cheng
Lai, Chia-Hsuan
author_facet Tsai, Yao-Te
Chen, Wen-Cheng
Hsu, Cheng-Ming
Tsai, Ming-Shao
Chang, Geng-He
Lee, Yi-Chan
Huang, Ethan I.
Fang, Chiung-Cheng
Lai, Chia-Hsuan
author_sort Tsai, Yao-Te
collection PubMed
description OBJECTIVES: For patients with oral cavity squamous cell carcinoma (OSCC), particularly for those with advanced disease, quality of life (QoL) is a key outcome measure. Therefore, we estimated survival-weighted psychometric scores (SWPS), life expectancy (LE), and quality-adjusted LE (QALE) in patients with advanced OSCC. METHODS AND MATERIALS: For estimation of survival function, we enrolled 2313 patients with advanced OSCC diagnosed between January 1, 2007, and December 31, 2013. The patients were followed until death or December 31, 2014. To acquire the QoL data, data from 194 patients were collected by employing the Taiwan Chinese versions of the Quality of Life Questionnaire Core 30 and Quality of Life Questionnaire Head and Neck 35 developed by the European Organisation for Research and Treatment of Cancer and the EQ-5D-3L between October 1, 2013, and December 31, 2017. The LE of the patients with OSCC were estimated through linear extrapolation of a logit-transformed curve. SWPS and QALE were determined by integrating the LE and corresponding QoL outcomes. RESULTS: For the patients with advanced OSCC, the estimated LE and QALE were 8.7 years and 7.7 quality-adjusted life years (QALYs), respectively. The loss of LE and QALE was 19.0 years and 20.0 QALYs, respectively. The estimated lifetime impairments of swallowing, speech, cognitive functioning, physical functioning, social functioning, and emotional functioning were 8.3, 6.5, 6.5, 6.1, 5.7, and 5.4 years, respectively. The estimated lifetime problems regarding mouth opening, teeth, social eating, and social contact were 6.6, 6.1, 7.5, and 6.1 years, respectively. The duration of feeding tube dependency was estimated to be 1.6 years. CONCLUSIONS: Patients with advanced OSCC had an estimated LE of 8.7 years and QALE of 7.7 QALYs. SWPS provided useful information regarding how advanced OSCC affects the subjective assessment of QoL. Our study results may serve as a reference for the allocation of cancer treatment resources.
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spelling pubmed-85116342021-10-14 Survival-Weighted Health Profiles in Patients Treated for Advanced Oral Cavity Squamous Cell Carcinoma Tsai, Yao-Te Chen, Wen-Cheng Hsu, Cheng-Ming Tsai, Ming-Shao Chang, Geng-He Lee, Yi-Chan Huang, Ethan I. Fang, Chiung-Cheng Lai, Chia-Hsuan Front Oncol Oncology OBJECTIVES: For patients with oral cavity squamous cell carcinoma (OSCC), particularly for those with advanced disease, quality of life (QoL) is a key outcome measure. Therefore, we estimated survival-weighted psychometric scores (SWPS), life expectancy (LE), and quality-adjusted LE (QALE) in patients with advanced OSCC. METHODS AND MATERIALS: For estimation of survival function, we enrolled 2313 patients with advanced OSCC diagnosed between January 1, 2007, and December 31, 2013. The patients were followed until death or December 31, 2014. To acquire the QoL data, data from 194 patients were collected by employing the Taiwan Chinese versions of the Quality of Life Questionnaire Core 30 and Quality of Life Questionnaire Head and Neck 35 developed by the European Organisation for Research and Treatment of Cancer and the EQ-5D-3L between October 1, 2013, and December 31, 2017. The LE of the patients with OSCC were estimated through linear extrapolation of a logit-transformed curve. SWPS and QALE were determined by integrating the LE and corresponding QoL outcomes. RESULTS: For the patients with advanced OSCC, the estimated LE and QALE were 8.7 years and 7.7 quality-adjusted life years (QALYs), respectively. The loss of LE and QALE was 19.0 years and 20.0 QALYs, respectively. The estimated lifetime impairments of swallowing, speech, cognitive functioning, physical functioning, social functioning, and emotional functioning were 8.3, 6.5, 6.5, 6.1, 5.7, and 5.4 years, respectively. The estimated lifetime problems regarding mouth opening, teeth, social eating, and social contact were 6.6, 6.1, 7.5, and 6.1 years, respectively. The duration of feeding tube dependency was estimated to be 1.6 years. CONCLUSIONS: Patients with advanced OSCC had an estimated LE of 8.7 years and QALE of 7.7 QALYs. SWPS provided useful information regarding how advanced OSCC affects the subjective assessment of QoL. Our study results may serve as a reference for the allocation of cancer treatment resources. Frontiers Media S.A. 2021-09-29 /pmc/articles/PMC8511634/ /pubmed/34660322 http://dx.doi.org/10.3389/fonc.2021.754412 Text en Copyright © 2021 Tsai, Chen, Hsu, Tsai, Chang, Lee, Huang, Fang and Lai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tsai, Yao-Te
Chen, Wen-Cheng
Hsu, Cheng-Ming
Tsai, Ming-Shao
Chang, Geng-He
Lee, Yi-Chan
Huang, Ethan I.
Fang, Chiung-Cheng
Lai, Chia-Hsuan
Survival-Weighted Health Profiles in Patients Treated for Advanced Oral Cavity Squamous Cell Carcinoma
title Survival-Weighted Health Profiles in Patients Treated for Advanced Oral Cavity Squamous Cell Carcinoma
title_full Survival-Weighted Health Profiles in Patients Treated for Advanced Oral Cavity Squamous Cell Carcinoma
title_fullStr Survival-Weighted Health Profiles in Patients Treated for Advanced Oral Cavity Squamous Cell Carcinoma
title_full_unstemmed Survival-Weighted Health Profiles in Patients Treated for Advanced Oral Cavity Squamous Cell Carcinoma
title_short Survival-Weighted Health Profiles in Patients Treated for Advanced Oral Cavity Squamous Cell Carcinoma
title_sort survival-weighted health profiles in patients treated for advanced oral cavity squamous cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511634/
https://www.ncbi.nlm.nih.gov/pubmed/34660322
http://dx.doi.org/10.3389/fonc.2021.754412
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