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Case Report: Corpus Callosotomy in a Cat With Drug-Resistant Epilepsy of Unknown Cause
A 2-month-old, intact male domestic shorthair cat with dullness, bilateral central blindness, and recurrent epileptic seizures was presented to a local clinic. Seizures were the generalized myoclonic and tonic-clonic type. Phenobarbital was initiated and maintained; however, seizures were not contro...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511771/ https://www.ncbi.nlm.nih.gov/pubmed/34660772 http://dx.doi.org/10.3389/fvets.2021.745063 |
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author | Hasegawa, Daisuke Asada, Rikako Mizuno, Satoshi Yu, Yoshihiko Hamamoto, Yuji Kanazono, Shinichi |
author_facet | Hasegawa, Daisuke Asada, Rikako Mizuno, Satoshi Yu, Yoshihiko Hamamoto, Yuji Kanazono, Shinichi |
author_sort | Hasegawa, Daisuke |
collection | PubMed |
description | A 2-month-old, intact male domestic shorthair cat with dullness, bilateral central blindness, and recurrent epileptic seizures was presented to a local clinic. Seizures were the generalized myoclonic and tonic-clonic type. Phenobarbital was initiated and maintained; however, seizures were not controlled. Other anti-seizure drugs, including levetiracetam, zonisamide, and diazepam, also provided insufficient seizure control with seizures occurring hourly to daily. By 8 months of age, the cat displayed non-ambulatory tetraparesis and deep somnolence. Magnetic resonance imaging (MRI), cerebrospinal fluid analysis, and pre- and post-prandial total bile acid analyses were unremarkable. Scalp electroencephalography (EEG) revealed central dominant but generally synchronized spikes and multiple spikes. The cat was diagnosed with drug-resistant epilepsy of unknown cause and was included in a clinical trial of epilepsy surgery. Given the unremarkable MRI and bilateral synchronized EEG abnormalities, a corpus callosotomy was performed at 12 months of age, and partial desynchronization of spikes was confirmed on EEG. Incomplete transection was found in the genu of the corpus callosum on postoperative MRI. After surgery, the mental status and ambulation clearly improved, and seizure frequency and duration were remarkably reduced. Recheck with follow-up EEG and MRI were performed at 3, 6, and 12 months after surgery. Scores of activities of daily living and visual analog scales including cat's and owner's quality of life had also improved considerably. This case report is the first documentation of the one-year clinical outcome of corpus callosotomy in a clinical feline case with drug-resistant epilepsy. |
format | Online Article Text |
id | pubmed-8511771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85117712021-10-14 Case Report: Corpus Callosotomy in a Cat With Drug-Resistant Epilepsy of Unknown Cause Hasegawa, Daisuke Asada, Rikako Mizuno, Satoshi Yu, Yoshihiko Hamamoto, Yuji Kanazono, Shinichi Front Vet Sci Veterinary Science A 2-month-old, intact male domestic shorthair cat with dullness, bilateral central blindness, and recurrent epileptic seizures was presented to a local clinic. Seizures were the generalized myoclonic and tonic-clonic type. Phenobarbital was initiated and maintained; however, seizures were not controlled. Other anti-seizure drugs, including levetiracetam, zonisamide, and diazepam, also provided insufficient seizure control with seizures occurring hourly to daily. By 8 months of age, the cat displayed non-ambulatory tetraparesis and deep somnolence. Magnetic resonance imaging (MRI), cerebrospinal fluid analysis, and pre- and post-prandial total bile acid analyses were unremarkable. Scalp electroencephalography (EEG) revealed central dominant but generally synchronized spikes and multiple spikes. The cat was diagnosed with drug-resistant epilepsy of unknown cause and was included in a clinical trial of epilepsy surgery. Given the unremarkable MRI and bilateral synchronized EEG abnormalities, a corpus callosotomy was performed at 12 months of age, and partial desynchronization of spikes was confirmed on EEG. Incomplete transection was found in the genu of the corpus callosum on postoperative MRI. After surgery, the mental status and ambulation clearly improved, and seizure frequency and duration were remarkably reduced. Recheck with follow-up EEG and MRI were performed at 3, 6, and 12 months after surgery. Scores of activities of daily living and visual analog scales including cat's and owner's quality of life had also improved considerably. This case report is the first documentation of the one-year clinical outcome of corpus callosotomy in a clinical feline case with drug-resistant epilepsy. Frontiers Media S.A. 2021-09-29 /pmc/articles/PMC8511771/ /pubmed/34660772 http://dx.doi.org/10.3389/fvets.2021.745063 Text en Copyright © 2021 Hasegawa, Asada, Mizuno, Yu, Hamamoto and Kanazono. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Hasegawa, Daisuke Asada, Rikako Mizuno, Satoshi Yu, Yoshihiko Hamamoto, Yuji Kanazono, Shinichi Case Report: Corpus Callosotomy in a Cat With Drug-Resistant Epilepsy of Unknown Cause |
title | Case Report: Corpus Callosotomy in a Cat With Drug-Resistant Epilepsy of Unknown Cause |
title_full | Case Report: Corpus Callosotomy in a Cat With Drug-Resistant Epilepsy of Unknown Cause |
title_fullStr | Case Report: Corpus Callosotomy in a Cat With Drug-Resistant Epilepsy of Unknown Cause |
title_full_unstemmed | Case Report: Corpus Callosotomy in a Cat With Drug-Resistant Epilepsy of Unknown Cause |
title_short | Case Report: Corpus Callosotomy in a Cat With Drug-Resistant Epilepsy of Unknown Cause |
title_sort | case report: corpus callosotomy in a cat with drug-resistant epilepsy of unknown cause |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511771/ https://www.ncbi.nlm.nih.gov/pubmed/34660772 http://dx.doi.org/10.3389/fvets.2021.745063 |
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