Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response

Aminoacyl-tRNA synthetases (ARSs) catalyze the charging of specific amino acids onto cognate tRNAs, an essential process for protein synthesis. Mutations in ARSs are frequently associated with a variety of human diseases. The human EPRS1 gene encodes a bifunctional glutamyl-prolyl-tRNA synthetase (E...

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Detalles Bibliográficos
Autores principales: Jin, Danni, Wek, Sheree A., Kudlapur, Nathan T., Cantara, William A., Bakhtina, Marina, Wek, Ronald C., Musier-Forsyth, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511952/
https://www.ncbi.nlm.nih.gov/pubmed/34537243
http://dx.doi.org/10.1016/j.jbc.2021.101203

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