Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells

Whereas proteolytic cleavage is crucial for peptide presentation by classical major histocompatibility complex (MHC) proteins to T cells, glycolipids presented by CD1 molecules are typically presented in an unmodified form. However, the mycobacterial lipid antigen mannosyl-β1-phosphomycoketide (MPM)...

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Detalles Bibliográficos
Autores principales: Reijneveld, Josephine F., Marino, Laura, Cao, Thinh-Phat, Cheng, Tan-Yun, Dam, Dennis, Shahine, Adam, Witte, Martin D., Filippov, Dmitri V., Suliman, Sara, van der Marel, Gijsbert A., Moody, D. Branch, Minnaard, Adriaan J., Rossjohn, Jamie, Codée, Jeroen D.C., Van Rhijn, Ildiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511953/
https://www.ncbi.nlm.nih.gov/pubmed/34536421
http://dx.doi.org/10.1016/j.jbc.2021.101197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511953/
https://www.ncbi.nlm.nih.gov/pubmed/34536421
http://dx.doi.org/10.1016/j.jbc.2021.101197

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