Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3

DNA methylation shows complex correlations with gene expression, and the role of promoter hypermethylation in repressing gene transcription has been well addressed. Emerging evidence indicates that gene body methylation promotes transcription; however, the underlying mechanisms remain to be further...

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Detalles Bibliográficos
Autores principales: Huang, Xiaoke, Zhang, Xuebin, Zong, Le, Gao, Qianqian, Zhang, Chao, Wei, Ran, Guan, Yiting, Huang, Li, Zhang, Lijun, Lyu, Guoliang, Tao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511956/
https://www.ncbi.nlm.nih.gov/pubmed/34520760
http://dx.doi.org/10.1016/j.jbc.2021.101195

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