Cargando…

Protective Effects of 6-Shogaol, an Active Compound of Ginger, in a Murine Model of Cisplatin-Induced Acute Kidney Injury

Acute kidney injury (AKI) is a dose-limiting side effect of cisplatin therapy in cancer patients. However, effective therapies for cisplatin-induced AKI are not available. Oxidative stress, tubular cell death, and inflammation are known to be the major pathological processes of the disease. 6-Shogao...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gwon, Mi-Gyeong, Gu, Hyemin, Leem, Jaechan, Park, Kwan-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512008/ https://www.ncbi.nlm.nih.gov/pubmed/34641472 http://dx.doi.org/10.3390/molecules26195931

Ejemplares similares

Oridonin Attenuates Cisplatin-Induced Acute Kidney Injury via Inhibiting Oxidative Stress, Apoptosis, and Inflammation in Mice
por: Gu, Hyemin, et al.
Publicado: (2022)

Protective Effects of Orexin A in a Murine Model of Cisplatin-Induced Acute Kidney Injury
por: Jo, Jungmin, et al.
Publicado: (2022)

STAT3/NF-κB decoy oligodeoxynucleotides inhibit atherosclerosis through regulation of the STAT/NF-κB signaling pathway in a mouse model of atherosclerosis
por: An, Hyun-Jin, et al.
Publicado: (2023)

The decoy oligodeoxynucleotide against HIF-1α and STAT5 ameliorates atopic dermatitis-like mouse model
por: Gwon, Mi-Gyeong, et al.
Publicado: (2023)

Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
por: Bischoff-Kont, Iris, et al.
Publicado: (2021)

Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice
por: Kim, Jung-Yeon, et al.
Publicado: (2019)

Therapeutic Effect of Bee Venom and Melittin on Skin Infection Caused by Streptococcus pyogenes
por: Bae, Seongjae, et al.
Publicado: (2022)

Therapeutic effects of bee venom on experimental atopic dermatitis
por: Gu, Hyemin, et al.
Publicado: (2018)

Beneficial Effects of SREBP Decoy Oligodeoxynucleotide in an Animal Model of Hyperlipidemia
por: An, Hyun-Jin, et al.
Publicado: (2020)

Bee Venom and Its Major Component Melittin Attenuated Cutibacterium acnes- and IGF-1-Induced Acne Vulgaris via Inactivation of Akt/mTOR/SREBP Signaling Pathway
por: Gu, Hyemin, et al.
Publicado: (2022)

Inhibition of p300 by Garcinol Protects against Cisplatin-Induced Acute Kidney Injury through Suppression of Oxidative Stress, Inflammation, and Tubular Cell Death in Mice
por: Kim, Jung-Yeon, et al.
Publicado: (2020)

Kahweol Ameliorates Cisplatin-Induced Acute Kidney Injury through Pleiotropic Effects in Mice
por: Kim, Jung-Yeon, et al.
Publicado: (2020)

Optimization of Extraction Conditions for the 6-Shogaol-rich Extract from Ginger (Zingiber officinale Roscoe)
por: Ok, Seon, et al.
Publicado: (2012)

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation
por: Liu, Rongxia, et al.
Publicado: (2015)

Inhibitory Effects of STAT3 Transcription Factor by Synthetic Decoy ODNs on Autophagy in Renal Fibrosis
por: Kim, Young-Ah, et al.
Publicado: (2021)

Anti-Fibrotic Effect of Synthetic Noncoding Oligodeoxynucleotide for Inhibiting mTOR and STAT3 via the Regulation of Autophagy in an Animal Model of Renal Injury
por: Jung, Hyun Jin, et al.
Publicado: (2022)

Synthetic Non-Coding RNA for Suppressing mTOR Translation to Prevent Renal Fibrosis Related to Autophagy in UUO Mouse Model
por: Kim, Young-Ah, et al.
Publicado: (2022)

Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects of Apamin in a Murine Model of Lipopolysaccharide-Induced Acute Kidney Injury
por: Kim, Jung-Yeon, et al.
Publicado: (2020)

Comparing the effects of microwave radiation on 6-gingerol and 6-shogaol from ginger rhizomes (Zingiber officinale Rosc)
por: Teng, Hui, et al.
Publicado: (2019)

6-Shogaol-Rich Extract from Ginger Up-Regulates the Antioxidant Defense Systems in Cells and Mice
por: Bak, Min-Ji, et al.
Publicado: (2012)

Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo
por: Chen, Huadong, et al.
Publicado: (2014)

6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells
por: Seow, Syntyche Ling Sing, et al.
Publicado: (2017)

Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
por: Bischoff-Kont, Iris, et al.
Publicado: (2022)

Ginger Constituent 6-Shogaol Attenuates Vincristine-Induced Activation of Mouse Gastroesophageal Vagal Afferent C-Fibers
por: Patil, Mayur J., et al.
Publicado: (2022)

Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice
por: Choi, Seung Hee, et al.
Publicado: (2017)

6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice
por: Wei, Chien-Kei, et al.
Publicado: (2017)

Formation of 6-, 8- and 10-Shogaol in Ginger through Application of Different Drying Methods: Altered Antioxidant and Antimicrobial Activity
por: Ghasemzadeh, Ali, et al.
Publicado: (2018)

Pharmacokinetics of 10-gingerol and 6-shogaol in the plasma of healthy subjects treated with red ginger (Zingiber officinale var. Rubrum) suspension
por: Levita, Jutti, et al.
Publicado: (2018)

6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in (Proteus Mirabilis)-Induced Parkinson’s Disease Mouse Model
por: Huh, Eugene, et al.
Publicado: (2023)

Protective Effects of Bee Venom against Endotoxemia-Related Acute Kidney Injury in Mice
por: Kim, Jung-Yeon, et al.
Publicado: (2020)

Glucuronidation of [6]-shogaol, [8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor
por: He, Liangliang, et al.
Publicado: (2018)

Metabolites of Ginger Component [6]-Shogaol Remain Bioactive in Cancer Cells and Have Low Toxicity in Normal Cells: Chemical Synthesis and Biological Evaluation
por: Zhu, Yingdong, et al.
Publicado: (2013)

Effect of the Ginger Derivative, 6-Shogaol, on Ferritin Levels in Patients With Low to Intermediate-1–Risk Myelodysplastic Syndrome—A Small, Investigative Study
por: Golombick, Terry, et al.
Publicado: (2017)

6-Shogaol, an Active Component of Ginger, Inhibits p300 Histone Acetyltransferase Activity and Attenuates the Development of Pressure-Overload-Induced Heart Failure
por: Kawase, Yuto, et al.
Publicado: (2023)

Pharmacokinetics and Tissue Distribution of Gingerols and Shogaols from Ginger (Zingiber officinale Rosc.) in Rats by UPLC–Q-Exactive–HRMS
por: Li, Ling-Ling, et al.
Publicado: (2019)

Simultaneous Determination of 6-Shogaol and 6-Gingerol in Various Ginger (Zingiber officinale Roscoe) Extracts and Commercial Formulations Using a Green RP-HPTLC-Densitometry Method
por: Foudah, Ahmed I., et al.
Publicado: (2020)

Protective Effects of Carnosol on Renal Interstitial Fibrosis in a Murine Model of Unilateral Ureteral Obstruction
por: Park, Jae-Hyung, et al.
Publicado: (2022)

The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation
por: Gu, Hyemin, et al.
Publicado: (2022)

Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice
por: Kim, Jung-Yeon, et al.
Publicado: (2018)

Ginger (Zingiber officinale) phytochemicals—gingerenone-A and shogaol inhibit SaHPPK: molecular docking, molecular dynamics simulations and in vitro approaches
por: Rampogu, Shailima, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ivema7ph32lpsco1qir66i5ran