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Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid

Hydrogels based on collagen/β-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxida...

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Detalles Bibliográficos
Autores principales: Michalska-Sionkowska, Marta, Warżyńska, Oliwia, Kaczmarek-Szczepańska, Beata, Łukowicz, Krzysztof, Osyczka, Anna Maria, Walczak, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512118/
https://www.ncbi.nlm.nih.gov/pubmed/34641227
http://dx.doi.org/10.3390/polym13193412
Descripción
Sumario:Hydrogels based on collagen/β-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxidant properties of the obtained hydrogels increased over the course of their incubation in culture media and were dependent on the concentration of tannic acid in the matrices. The obtained materials influenced dehydrogenase activity and the ATP level of pathogens. Additionally, the materials’ extracts improved the HaCaT cells’ viability. Therefore, the obtained hydrogels seem to be promising biocompatible materials which display antimicrobial properties.