Cargando…

Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid

Hydrogels based on collagen/β-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxida...

Descripción completa

Detalles Bibliográficos
Autores principales: Michalska-Sionkowska, Marta, Warżyńska, Oliwia, Kaczmarek-Szczepańska, Beata, Łukowicz, Krzysztof, Osyczka, Anna Maria, Walczak, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512118/
https://www.ncbi.nlm.nih.gov/pubmed/34641227
http://dx.doi.org/10.3390/polym13193412
_version_ 1784582913951531008
author Michalska-Sionkowska, Marta
Warżyńska, Oliwia
Kaczmarek-Szczepańska, Beata
Łukowicz, Krzysztof
Osyczka, Anna Maria
Walczak, Maciej
author_facet Michalska-Sionkowska, Marta
Warżyńska, Oliwia
Kaczmarek-Szczepańska, Beata
Łukowicz, Krzysztof
Osyczka, Anna Maria
Walczak, Maciej
author_sort Michalska-Sionkowska, Marta
collection PubMed
description Hydrogels based on collagen/β-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxidant properties of the obtained hydrogels increased over the course of their incubation in culture media and were dependent on the concentration of tannic acid in the matrices. The obtained materials influenced dehydrogenase activity and the ATP level of pathogens. Additionally, the materials’ extracts improved the HaCaT cells’ viability. Therefore, the obtained hydrogels seem to be promising biocompatible materials which display antimicrobial properties.
format Online
Article
Text
id pubmed-8512118
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85121182021-10-14 Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid Michalska-Sionkowska, Marta Warżyńska, Oliwia Kaczmarek-Szczepańska, Beata Łukowicz, Krzysztof Osyczka, Anna Maria Walczak, Maciej Polymers (Basel) Article Hydrogels based on collagen/β-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxidant properties of the obtained hydrogels increased over the course of their incubation in culture media and were dependent on the concentration of tannic acid in the matrices. The obtained materials influenced dehydrogenase activity and the ATP level of pathogens. Additionally, the materials’ extracts improved the HaCaT cells’ viability. Therefore, the obtained hydrogels seem to be promising biocompatible materials which display antimicrobial properties. MDPI 2021-10-05 /pmc/articles/PMC8512118/ /pubmed/34641227 http://dx.doi.org/10.3390/polym13193412 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Michalska-Sionkowska, Marta
Warżyńska, Oliwia
Kaczmarek-Szczepańska, Beata
Łukowicz, Krzysztof
Osyczka, Anna Maria
Walczak, Maciej
Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid
title Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid
title_full Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid
title_fullStr Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid
title_full_unstemmed Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid
title_short Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid
title_sort characterization of collagen/beta glucan hydrogels crosslinked with tannic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512118/
https://www.ncbi.nlm.nih.gov/pubmed/34641227
http://dx.doi.org/10.3390/polym13193412
work_keys_str_mv AT michalskasionkowskamarta characterizationofcollagenbetaglucanhydrogelscrosslinkedwithtannicacid
AT warzynskaoliwia characterizationofcollagenbetaglucanhydrogelscrosslinkedwithtannicacid
AT kaczmarekszczepanskabeata characterizationofcollagenbetaglucanhydrogelscrosslinkedwithtannicacid
AT łukowiczkrzysztof characterizationofcollagenbetaglucanhydrogelscrosslinkedwithtannicacid
AT osyczkaannamaria characterizationofcollagenbetaglucanhydrogelscrosslinkedwithtannicacid
AT walczakmaciej characterizationofcollagenbetaglucanhydrogelscrosslinkedwithtannicacid