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Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synth...

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Detalles Bibliográficos
Autores principales:	Sim, Jaehoon, Jang, Eunbin, Kim, Hyun Jin, Jeon, Hongjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512135/ https://www.ncbi.nlm.nih.gov/pubmed/34641481 http://dx.doi.org/10.3390/molecules26195938

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