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Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management
Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the synergistic effect of paclitaxel (PAX) and resveratrol (RESV)-loaded Soluplus polymeric nanoparticles (PNPs) against glioma cell lines along with in viv...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512154/ https://www.ncbi.nlm.nih.gov/pubmed/34641026 http://dx.doi.org/10.3390/polym13193210 |
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author | Hussain, Talib Paranthaman, Sathishbabu Rizvi, Syed Mohd Danish Moin, Afrasim Gowda, Devegowda Vishakante Subaiea, Gehad Muhammed Ansari, Mukhtar Alanazi, Abulrahman Sattam |
author_facet | Hussain, Talib Paranthaman, Sathishbabu Rizvi, Syed Mohd Danish Moin, Afrasim Gowda, Devegowda Vishakante Subaiea, Gehad Muhammed Ansari, Mukhtar Alanazi, Abulrahman Sattam |
author_sort | Hussain, Talib |
collection | PubMed |
description | Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the synergistic effect of paclitaxel (PAX) and resveratrol (RESV)-loaded Soluplus polymeric nanoparticles (PNPs) against glioma cell lines along with in vivo pharmacokinetics and brain distribution study. PAX-RESV-loaded PNPs were prepared by the thin film hydration technique and optimized for different dependent and independent variables by using DoE (Design-Expert) software. The in vitro physiochemical characterization of prepared PAX-RESV-loaded PNPs exhibited appropriate particle size, PDI and % encapsulation efficiency. Cytotoxicity assay revealed that PTX-RESV loaded PNPs had a synergistic antitumor efficacy against C6 glioma cells compared with single and combined pure drugs. Finally, the pharmacokinetic and brain distribution studies in mice demonstrated that the PNPs significantly enhanced the bioavailability of PTX-RESV PNPs than pure PAX and RESV. Thus, the study concluded that PAX-RESV PNPs combination could significantly enhance anti-glioma activity, and this could be developed into a potential glioma treatment strategy. |
format | Online Article Text |
id | pubmed-8512154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85121542021-10-14 Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management Hussain, Talib Paranthaman, Sathishbabu Rizvi, Syed Mohd Danish Moin, Afrasim Gowda, Devegowda Vishakante Subaiea, Gehad Muhammed Ansari, Mukhtar Alanazi, Abulrahman Sattam Polymers (Basel) Article Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the synergistic effect of paclitaxel (PAX) and resveratrol (RESV)-loaded Soluplus polymeric nanoparticles (PNPs) against glioma cell lines along with in vivo pharmacokinetics and brain distribution study. PAX-RESV-loaded PNPs were prepared by the thin film hydration technique and optimized for different dependent and independent variables by using DoE (Design-Expert) software. The in vitro physiochemical characterization of prepared PAX-RESV-loaded PNPs exhibited appropriate particle size, PDI and % encapsulation efficiency. Cytotoxicity assay revealed that PTX-RESV loaded PNPs had a synergistic antitumor efficacy against C6 glioma cells compared with single and combined pure drugs. Finally, the pharmacokinetic and brain distribution studies in mice demonstrated that the PNPs significantly enhanced the bioavailability of PTX-RESV PNPs than pure PAX and RESV. Thus, the study concluded that PAX-RESV PNPs combination could significantly enhance anti-glioma activity, and this could be developed into a potential glioma treatment strategy. MDPI 2021-09-22 /pmc/articles/PMC8512154/ /pubmed/34641026 http://dx.doi.org/10.3390/polym13193210 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hussain, Talib Paranthaman, Sathishbabu Rizvi, Syed Mohd Danish Moin, Afrasim Gowda, Devegowda Vishakante Subaiea, Gehad Muhammed Ansari, Mukhtar Alanazi, Abulrahman Sattam Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management |
title | Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management |
title_full | Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management |
title_fullStr | Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management |
title_full_unstemmed | Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management |
title_short | Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management |
title_sort | fabrication and characterization of paclitaxel and resveratrol loaded soluplus polymeric nanoparticles for improved bbb penetration for glioma management |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512154/ https://www.ncbi.nlm.nih.gov/pubmed/34641026 http://dx.doi.org/10.3390/polym13193210 |
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