A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the development of vaccines is the antibody-dependen...

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Autores principales: Sánchez-Zuno, Gabriela Athziri, Matuz-Flores, Mónica Guadalupe, González-Estevez, Guillermo, Nicoletti, Ferdinando, Turrubiates-Hernández, Francisco Javier, Mangano, Katia, Muñoz-Valle, José Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512237/
https://www.ncbi.nlm.nih.gov/pubmed/34632844
http://dx.doi.org/10.1177/20587384211050199
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author Sánchez-Zuno, Gabriela Athziri
Matuz-Flores, Mónica Guadalupe
González-Estevez, Guillermo
Nicoletti, Ferdinando
Turrubiates-Hernández, Francisco Javier
Mangano, Katia
Muñoz-Valle, José Francisco
author_facet Sánchez-Zuno, Gabriela Athziri
Matuz-Flores, Mónica Guadalupe
González-Estevez, Guillermo
Nicoletti, Ferdinando
Turrubiates-Hernández, Francisco Javier
Mangano, Katia
Muñoz-Valle, José Francisco
author_sort Sánchez-Zuno, Gabriela Athziri
collection PubMed
description The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the development of vaccines is the antibody-dependent enhancement phenomenon, better known as ADE. In this review, we provide an overview of SARS-CoV-2 infection as well as the immune response generated by the host. On the bases of this principle, we also describe what is known about the ADE phenomenon in various viral infections and its possible role as a limiting factor in the development of new vaccines and therapeutic strategies.
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spelling pubmed-85122372021-10-14 A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies Sánchez-Zuno, Gabriela Athziri Matuz-Flores, Mónica Guadalupe González-Estevez, Guillermo Nicoletti, Ferdinando Turrubiates-Hernández, Francisco Javier Mangano, Katia Muñoz-Valle, José Francisco Int J Immunopathol Pharmacol Letter to the Editor The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the development of vaccines is the antibody-dependent enhancement phenomenon, better known as ADE. In this review, we provide an overview of SARS-CoV-2 infection as well as the immune response generated by the host. On the bases of this principle, we also describe what is known about the ADE phenomenon in various viral infections and its possible role as a limiting factor in the development of new vaccines and therapeutic strategies. SAGE Publications 2021-10-10 /pmc/articles/PMC8512237/ /pubmed/34632844 http://dx.doi.org/10.1177/20587384211050199 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Letter to the Editor
Sánchez-Zuno, Gabriela Athziri
Matuz-Flores, Mónica Guadalupe
González-Estevez, Guillermo
Nicoletti, Ferdinando
Turrubiates-Hernández, Francisco Javier
Mangano, Katia
Muñoz-Valle, José Francisco
A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
title A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
title_full A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
title_fullStr A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
title_full_unstemmed A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
title_short A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
title_sort review: antibody-dependent enhancement in covid-19: the not so friendly side of antibodies
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512237/
https://www.ncbi.nlm.nih.gov/pubmed/34632844
http://dx.doi.org/10.1177/20587384211050199
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