Cargando…

Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry

Chemical biology and drug discovery are two scientific activities that pursue different goals but complement each other. The former is an interventional science that aims at understanding living systems through the modulation of its molecular components with compounds designed for this purpose. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deprez, Benoit, Bosc, Damien, Charton, Julie, Couturier, Cyril, Deprez-Poulain, Rebecca, Flipo, Marion, Leroux, Florence, Villemagne, Baptiste, Willand, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512331/ https://www.ncbi.nlm.nih.gov/pubmed/34641626 http://dx.doi.org/10.3390/molecules26196083

Ejemplares similares

Rapid and Efficient Access to Novel Bio-Inspired 3-Dimensional Tricyclic SpiroLactams as Privileged Structures via Meyers’ Lactamization
por: Tangara, Salia, et al.
Publicado: (2023)

Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?
por: Lesire, Laetitia, et al.
Publicado: (2022)

Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases
por: Dam, Sushovan, et al.
Publicado: (2022)

On the Hunt for Next-Generation Antimicrobial Agents: An Online Symposium Organized Jointly by the French Society for Medicinal Chemistry (Société de Chimie Thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) on 9–10 December 2021
por: Antraygues, Kevin, et al.
Publicado: (2022)

Setting Up a Bioluminescence Resonance Energy Transfer High throughput Screening Assay to Search for Protein/Protein Interaction Inhibitors in Mammalian Cells
por: Couturier, Cyril, et al.
Publicado: (2012)

Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification
por: Faïon, Léo, et al.
Publicado: (2023)

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
por: Deprez-Poulain, Rebecca, et al.
Publicado: (2015)

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
por: Camberlein, Virgyl, et al.
Publicado: (2022)

Click Reactions in Medicinal Chemistry
por: Bosc, Damien
Publicado: (2023)

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis
por: Machelart, Arnaud, et al.
Publicado: (2019)

Intraobserver and interobserver reliability of computed tomography measurements of the soft palate in French bulldogs
por: Deprez, Pauline, et al.
Publicado: (2019)

Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles
por: Costa-Gouveia, Joana, et al.
Publicado: (2018)

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles
por: Costa-Gouveia, Joana, et al.
Publicado: (2017)

Characteristics of Patients Treated with JAK Inhibitors in Rheumatoid Arthritis before versus after VTE Risk Warnings
por: Philippoteaux, Cécile, et al.
Publicado: (2022)

Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control Study
por: Desvages, Anne, et al.
Publicado: (2023)

Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods
por: Reynès, Christelle, et al.
Publicado: (2010)

Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses
por: Brier, Lucile, et al.
Publicado: (2023)

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
por: Plé, Coline, et al.
Publicado: (2022)

An illustrated history of French cuisine, from Charlemagne to Charles de Gaulle.
por: Guy, Christian
Publicado: (1962)

Les enfants bilingues : langues et familles
por: Deprez, Christine
Publicado: (1994)

“Anterior” chemabrasion for acne scars treatment
por: Deprez, Philippe
Publicado: (2019)

Fetal body MRI and its application to fetal and neonatal treatment: an illustrative review
por: Davidson, Joseph R, et al.
Publicado: (2021)

Endoscopic submucosal dissection (ESD): still a matter for debate or a gold standard technique in both Western and Eastern countries?
por: Deprez, Pierre H.
Publicado: (2014)

Barrett's esophagus: The advocacy for ESD
por: Deprez, Pierre H.
Publicado: (2016)

Biliary drainage in case of surgically altered anatomy: How to select the first line approach?
por: Deprez, Pierre H.
Publicado: (2016)

Regulation of adult neurogenesis by GABAergic transmission: signaling beyond GABA(A)-receptors
por: Pallotto, Marta, et al.
Publicado: (2014)

LUMINAL PLENARY: OR-LUM-02: Endoscopic ultrasound-guided fine needle aspiration for liver lesions: Comparative results in a large series of more than 150 patients with primary and secondary tumors
por: Mouradides, Christina, et al.
Publicado: (2017)

A Rare Case of Extrinsic Stenosis of Dural Sinus
por: Boyer, Axel, et al.
Publicado: (2022)

SOR Project: the French context
por: Durand-Zaleski, I, et al.
Publicado: (2001)

Hi-Lumi Project Procedures Illustrations
por: Abdelhamid, Omar
Publicado: (2023)

Unusual Delayed FDG-PET/CT Hypermetabolism Due to Charcoal-Induced Granuloma
por: Rahier, Quentin, et al.
Publicado: (2018)

Post-Traumatic Ostial Avulsion of a Polar Inferior Renal Artery Treated by Endovascular Covered Aortic Stenting
por: Carrozza, François, et al.
Publicado: (2020)

Endovascular Repositioning of a Central Venous Port Malposition in the Internal Thoracic Vein
por: Salavracos, Mike, et al.
Publicado: (2021)

EHPnet: Green Chemistry Institute
por: Dooley, Erin E.
Publicado: (2007)

Illustrated guide to home chemistry experiments: all lab, no lecture
por: Thompson, Robert Bruce
Publicado: (2008)

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System
por: Deckmyn, Benjamin, et al.
Publicado: (2022)

Triphenylamines Induce Cell Death Upon 2-Photon Excitation
por: Chennoufi, Rahima, et al.
Publicado: (2017)

Analytical chemistry of the Manhattan project
por: Rodden, Clement J
Publicado: (1950)

Different Pathways Leading to Integrase Inhibitors Resistance
por: Thierry, Eloïse, et al.
Publicado: (2017)

BSR Annual Meeting 2018: Interventional Radiology
por: Deprez, Fabrice C., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7j9dorjo2t54iks9lkvtoekkmj