Convenient Preparation and Spectroscopic Characterization of 7R-Hydroxymatairesinol

The preparation of 7R-HMR (allo-hydroxymatairesinol) is reported by: (a) NaBH(4) kinetic reduction of 7R/7S diastereomeric mixture; and (b) epimerization of the C7 hydroxyl group by Mitsunobu reaction and subsequent ester hydrolysis. The availability of highly pure target compound (7R-HMR) made it p...

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Detalles Bibliográficos
Autores principales: Colombo, Eleonora, Paladino, Giuseppe, Ciriello, Umberto, Passarella, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512340/
https://www.ncbi.nlm.nih.gov/pubmed/34641381
http://dx.doi.org/10.3390/molecules26195838
Descripción
Sumario:The preparation of 7R-HMR (allo-hydroxymatairesinol) is reported by: (a) NaBH(4) kinetic reduction of 7R/7S diastereomeric mixture; and (b) epimerization of the C7 hydroxyl group by Mitsunobu reaction and subsequent ester hydrolysis. The availability of highly pure target compound (7R-HMR) made it possible to confirm the structure of the target compound and to complete the full spectroscopic characterization.

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