Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides

Herein, we report a Kumada cross-coupling reaction of benzylic sulfonamides. The scope of the transformation includes acyclic and cyclic sulfonamide precursors that cleanly produce highly substituted acyclic fragments. Preliminary data are consistent with a stereospecific mechanism that allows for a...

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Detalles Bibliográficos
Autores principales: Hewitt, Kirsten A., Herbert, Claire A., Matus, Alissa C., Jarvo, Elizabeth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512530/
https://www.ncbi.nlm.nih.gov/pubmed/34641491
http://dx.doi.org/10.3390/molecules26195947
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author Hewitt, Kirsten A.
Herbert, Claire A.
Matus, Alissa C.
Jarvo, Elizabeth R.
author_facet Hewitt, Kirsten A.
Herbert, Claire A.
Matus, Alissa C.
Jarvo, Elizabeth R.
author_sort Hewitt, Kirsten A.
collection PubMed
description Herein, we report a Kumada cross-coupling reaction of benzylic sulfonamides. The scope of the transformation includes acyclic and cyclic sulfonamide precursors that cleanly produce highly substituted acyclic fragments. Preliminary data are consistent with a stereospecific mechanism that allows for a diastereoselective reaction.
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spelling pubmed-85125302021-10-14 Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides Hewitt, Kirsten A. Herbert, Claire A. Matus, Alissa C. Jarvo, Elizabeth R. Molecules Communication Herein, we report a Kumada cross-coupling reaction of benzylic sulfonamides. The scope of the transformation includes acyclic and cyclic sulfonamide precursors that cleanly produce highly substituted acyclic fragments. Preliminary data are consistent with a stereospecific mechanism that allows for a diastereoselective reaction. MDPI 2021-09-30 /pmc/articles/PMC8512530/ /pubmed/34641491 http://dx.doi.org/10.3390/molecules26195947 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Hewitt, Kirsten A.
Herbert, Claire A.
Matus, Alissa C.
Jarvo, Elizabeth R.
Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides
title Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides
title_full Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides
title_fullStr Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides
title_full_unstemmed Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides
title_short Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides
title_sort nickel-catalyzed kumada cross-coupling reactions of benzylic sulfonamides
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512530/
https://www.ncbi.nlm.nih.gov/pubmed/34641491
http://dx.doi.org/10.3390/molecules26195947
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