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New Methods for the Synthesis of Spirocyclic Cephalosporin Analogues

Spiro compounds provide attractive targets in drug discovery due to their inherent three-dimensional structures, which enhance protein interactions, aid solubility and facilitate molecular modelling. However, synthetic methodology for the spiro-functionalisation of important classes of penicillin an...

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Detalles Bibliográficos
Autores principales:	Zhao, Alan X., Horsfall, Louise E., Hulme, Alison N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512572/ https://www.ncbi.nlm.nih.gov/pubmed/34641579 http://dx.doi.org/10.3390/molecules26196035

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