A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome

Paraneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation...

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Autores principales: Nakashima, Koki, Fujii, Yuya, Sato, Masayuki, Igarashi, Kazunari, Kobayashi, Motohiro, Ishizuka, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512629/
https://www.ncbi.nlm.nih.gov/pubmed/34692399
http://dx.doi.org/10.1016/j.rmcr.2021.101525
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author Nakashima, Koki
Fujii, Yuya
Sato, Masayuki
Igarashi, Kazunari
Kobayashi, Motohiro
Ishizuka, Tamotsu
author_facet Nakashima, Koki
Fujii, Yuya
Sato, Masayuki
Igarashi, Kazunari
Kobayashi, Motohiro
Ishizuka, Tamotsu
author_sort Nakashima, Koki
collection PubMed
description Paraneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation of treatment with an immune checkpoint inhibitor. Blood test results revealed anti-amphiphysin (AMPH) antibody positively, leading to the diagnosis of PNS. The disturbance of consciousness was improved with intravenous administration of steroid and immunoglobulin. To our knowledge, this is the first report of anti-AMPH antibody-positive PNS in a patient with NSCLC.
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spelling pubmed-85126292021-10-21 A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome Nakashima, Koki Fujii, Yuya Sato, Masayuki Igarashi, Kazunari Kobayashi, Motohiro Ishizuka, Tamotsu Respir Med Case Rep Case Report Paraneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation of treatment with an immune checkpoint inhibitor. Blood test results revealed anti-amphiphysin (AMPH) antibody positively, leading to the diagnosis of PNS. The disturbance of consciousness was improved with intravenous administration of steroid and immunoglobulin. To our knowledge, this is the first report of anti-AMPH antibody-positive PNS in a patient with NSCLC. Elsevier 2021-10-07 /pmc/articles/PMC8512629/ /pubmed/34692399 http://dx.doi.org/10.1016/j.rmcr.2021.101525 Text en © 2021 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakashima, Koki
Fujii, Yuya
Sato, Masayuki
Igarashi, Kazunari
Kobayashi, Motohiro
Ishizuka, Tamotsu
A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome
title A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome
title_full A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome
title_fullStr A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome
title_full_unstemmed A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome
title_short A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome
title_sort case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512629/
https://www.ncbi.nlm.nih.gov/pubmed/34692399
http://dx.doi.org/10.1016/j.rmcr.2021.101525
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