Cargando…
Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model
[Image: see text] Worldwide, cancer is the second leading cause of death. Regardless of the continuous progress in medicine, we still do not have a fully effective anti-cancer therapy. Therefore, the search for new targeted anti-cancer drugs is still an unmet need. Here, we present novel protein–dru...
Autores principales: | Krzyscik, Mateusz A., Zakrzewska, Malgorzata, Sørensen, Vigdis, Øy, Geir Frode, Brunheim, Skjalg, Haugsten, Ellen M., Mælandsmo, Gunhild M., Wiedlocha, Antoni, Otlewski, Jacek |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512659/ https://www.ncbi.nlm.nih.gov/pubmed/34542998 http://dx.doi.org/10.1021/acs.biomac.1c00662 |
Ejemplares similares
-
Cytotoxic Conjugates of Fibroblast Growth Factor 2
(FGF2) with Monomethyl Auristatin E for Effective Killing of Cells
Expressing FGF Receptors
por: Krzyscik, Mateusz Adam, et al.
Publicado: (2017) -
Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1
por: Nawrocka, Daria, et al.
Publicado: (2023) -
Site-Specific, Stoichiometric-Controlled, PEGylated
Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin
Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast
Growth Factor Receptor 1 (FGFR1)
por: Krzyscik, Mateusz Adam, et al.
Publicado: (2020) -
FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1
por: Świderska, Karolina Weronika, et al.
Publicado: (2018) -
Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells
por: Damiani, Isabella, et al.
Publicado: (2021)