Research Progress of Small Molecule Fluorescent Probes for Detecting Hypochlorite

Hypochlorous acid (HOCl) generates from the reaction between hydrogen peroxide and chloride ions via myeloperoxidase (MPO)-mediated in vivo. As very important reactive oxygen species (ROS), hypochlorous acid (HOCl)/hypochlorite (OCl(−)) play a crucial role in a variety of physiological and pathological processes. However, excessive or misplaced production of HOCl/OCl(−) can cause variety of tissue damage and human diseases. Therefore, rapid, sensitive, and selective detection of OCl(−) is very important. In recent years, the fluorescent probe method for detecting hypochlorous acid has been developed rapidly due to its simple operation, low toxicity, high sensitivity, and high selectivity. In this review, the progress of recently discovered fluorescent probes for the detection of hypochlorous acid was summarized with the aim to provide useful information for further design of better fluorescent probes.