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Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property

Finding a simple and eco-friendly production technique that matches to the natural agent and results in a truly valuable natural scaffold production is still limited amongst the intensively competitive natural scaffold development. Therefore, the purpose of this study was to develop natural scaffold...

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Autores principales: Napavichayanun, Supamas, Pienpinijtham, Prompong, Reddy, Narendra, Aramwit, Pornanong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512865/
https://www.ncbi.nlm.nih.gov/pubmed/34641182
http://dx.doi.org/10.3390/polym13193370
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author Napavichayanun, Supamas
Pienpinijtham, Prompong
Reddy, Narendra
Aramwit, Pornanong
author_facet Napavichayanun, Supamas
Pienpinijtham, Prompong
Reddy, Narendra
Aramwit, Pornanong
author_sort Napavichayanun, Supamas
collection PubMed
description Finding a simple and eco-friendly production technique that matches to the natural agent and results in a truly valuable natural scaffold production is still limited amongst the intensively competitive natural scaffold development. Therefore, the purpose of this study was to develop natural scaffolds that were environmentally friendly, low cost, and easily produced, using natural agents and a physical crosslinking technique. These scaffolds were prepared from agarose and sericin using the freeze-drying method (D) or freeze-thawing together with the freeze-drying method (TD). Moreover, plasticizers were added into the scaffold to improve their properties. Their physical, mechanical, and biological properties were investigated. The results showed that scaffolds that were prepared using the TD method had stronger bonding between sericin and other compounds, leading to a low swelling ratio and low protein release of the scaffolds. This property may be applied in the development of further material as a controlled drug release scaffold. Adding plasticizers, especially glycerin, into the scaffolds significantly increased elongation properties, leading to an increase in elasticity of the scaffold. Moreover, all scaffolds could activate cell migration, which had an advantage on wound healing acceleration. Accordingly, this study was successful in developing natural scaffolds using natural agents and simple and green crosslinking methods.
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spelling pubmed-85128652021-10-14 Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property Napavichayanun, Supamas Pienpinijtham, Prompong Reddy, Narendra Aramwit, Pornanong Polymers (Basel) Article Finding a simple and eco-friendly production technique that matches to the natural agent and results in a truly valuable natural scaffold production is still limited amongst the intensively competitive natural scaffold development. Therefore, the purpose of this study was to develop natural scaffolds that were environmentally friendly, low cost, and easily produced, using natural agents and a physical crosslinking technique. These scaffolds were prepared from agarose and sericin using the freeze-drying method (D) or freeze-thawing together with the freeze-drying method (TD). Moreover, plasticizers were added into the scaffold to improve their properties. Their physical, mechanical, and biological properties were investigated. The results showed that scaffolds that were prepared using the TD method had stronger bonding between sericin and other compounds, leading to a low swelling ratio and low protein release of the scaffolds. This property may be applied in the development of further material as a controlled drug release scaffold. Adding plasticizers, especially glycerin, into the scaffolds significantly increased elongation properties, leading to an increase in elasticity of the scaffold. Moreover, all scaffolds could activate cell migration, which had an advantage on wound healing acceleration. Accordingly, this study was successful in developing natural scaffolds using natural agents and simple and green crosslinking methods. MDPI 2021-09-30 /pmc/articles/PMC8512865/ /pubmed/34641182 http://dx.doi.org/10.3390/polym13193370 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Napavichayanun, Supamas
Pienpinijtham, Prompong
Reddy, Narendra
Aramwit, Pornanong
Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property
title Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property
title_full Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property
title_fullStr Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property
title_full_unstemmed Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property
title_short Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property
title_sort superior technique for the production of agarose dressing containing sericin and its wound healing property
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512865/
https://www.ncbi.nlm.nih.gov/pubmed/34641182
http://dx.doi.org/10.3390/polym13193370
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