Cargando…

Integrated Network Pharmacology Analysis and In Vitro Validation Revealed the Potential Active Components and Underlying Mechanistic Pathways of Herba Patriniae in Colorectal Cancer

Herba Patriniae (HP) are medicinal plants commonly used in colorectal cancer (CRC) patients. In this study, network pharmacology was used to predict the active components and key signaling pathways of HP in CRC. Patrinia heterophylla, one type of HP, was chosen for validation of the network pharmaco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Huihai, Cheung, Man-Kit, Yue, Grace Gar-Lee, Leung, Ping-Chung, Wong, Chun-Kwok, Lau, Clara Bik-San
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513027/ https://www.ncbi.nlm.nih.gov/pubmed/34641576 http://dx.doi.org/10.3390/molecules26196032

Ejemplares similares

Discovery of a heat-generated compound DHD derived from Patrinia villosa water extract with inhibitory effects on colon cancer cells viability and migration
por: Yang, Huihai, et al.
Publicado: (2023)

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control
por: Gong, Linna, et al.
Publicado: (2021)

A review on the immunomodulatory activity of Acanthopanax senticosus and its active components
por: Lau, Kit-Man, et al.
Publicado: (2019)

Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae
por: Fu, Bo, et al.
Publicado: (2017)

A Review of the Effects of Natural Compounds, Medicinal Plants, and Mushrooms on the Gut Microbiota in Colitis and Cancer
por: Cheung, Man Kit, et al.
Publicado: (2020)

The adjuvant value of Herba Cistanches when used in combination with statin in murine models
por: Wat, Elaine, et al.
Publicado: (2017)

Method establishment for upgrading chemical markers in pharmacopoeia to bioactive markers for biological standardization of traditional Chinese medicine
por: Lau, Clara Bik-San, et al.
Publicado: (2018)

Medicinal Plants and Mushrooms with Immunomodulatory and Anticancer Properties—A Review on Hong Kong’s Experience
por: Yue, Grace Gar-Lee, et al.
Publicado: (2021)

Turmeric Is Therapeutic in Vivo on Patient-Derived Colorectal Cancer Xenografts: Inhibition of Growth, Metastasis, and Tumor Recurrence
por: Li, Mingyue, et al.
Publicado: (2021)

Stachyose: One of the Active Fibroblast-proliferating Components in the Root of Rehmanniae Radix (地黃 dì huáng)
por: Lai, Patrick Kwok-Kin, et al.
Publicado: (2012)

Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo
por: Chan, Ben Chung Lap, et al.
Publicado: (2021)

Iridoids and active ones in patrinia: A review
por: Wang, Li, et al.
Publicado: (2023)

Is Danggui Safe to be Taken by Breast Cancer Patients?—A Skepticism Finally Answered by Comprehensive Preclinical Evidence
por: Yue, Grace Gar-Lee, et al.
Publicado: (2019)

The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro
por: Xie, Fang, et al.
Publicado: (2005)

Novel PI3K/AKT targeting anti-angiogenic activities of 4-vinylphenol, a new therapeutic potential of a well-known styrene metabolite
por: Yue, Grace Gar-Lee, et al.
Publicado: (2015)

RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation
por: Leung, Hoi-Wing, et al.
Publicado: (2015)

Actein Inhibits the Proliferation and Adhesion of Human Breast Cancer Cells and Suppresses Migration in vivo
por: Wu, Xiao-Xiao, et al.
Publicado: (2018)

Actein Inhibits Tumor Growth and Metastasis in HER2-Positive Breast Tumor Bearing Mice via Suppressing AKT/mTOR and Ras/Raf/MAPK Signaling Pathways
por: Wu, Xiao-Xiao, et al.
Publicado: (2020)

Therapeutic effect and metabolomics mechanism of Patrinia Villosa (Thunb.) juss on liver injury in rats
por: Qiao, Li-Man, et al.
Publicado: (2022)

Nine Unique Iridoids and Iridoid Glycosides From Patrinia scabiosaefolia
por: Liu, Zhenhua, et al.
Publicado: (2021)

Prediction of habitat suitability for Patrinia sibirica Juss. in the Southern Urals
por: Fedorov, Nikolai, et al.
Publicado: (2021)

Network Pharmacology‐Based Study on the Active Component and Mechanism of the Anti-Gastric-Cancer Effect of Herba Sarcandrae
por: Han, Li, et al.
Publicado: (2021)

Investigating the Mechanism of Scutellariae barbata Herba in the Treatment of Colorectal Cancer by Network Pharmacology and Molecular Docking
por: Qi, Xiangjun, et al.
Publicado: (2021)

Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species
por: Li, Mingyue, et al.
Publicado: (2017)

An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model
por: Yue, Grace Gar-Lee, et al.
Publicado: (2018)

Integrated bioinformatics analysis and network pharmacology to explore the potential mechanism of Patrinia heterophylla Bunge against acute promyelocytic leukemia
por: Feng, Liya, et al.
Publicado: (2023)

Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis
por: Liu, Xin, et al.
Publicado: (2023)

The adjuvant value of Andrographis paniculata in metastatic esophageal cancer treatment – from preclinical perspectives
por: Li, Lin, et al.
Publicado: (2017)

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment
por: Yue, Grace Gar-Lee, et al.
Publicado: (2016)

A Natural Flavone Tricin from Grains Can Alleviate Tumor Growth and Lung Metastasis in Colorectal Tumor Mice
por: Yue, Grace Gar-Lee, et al.
Publicado: (2020)

A New Biphenyl Neolignan from Leaves of Patrinia villosa (Thunb.) Juss.
por: Xin-Jia, Yan, et al.
Publicado: (2016)

Two New Iridoid Glucosides from the Whole Plant of Patrinia scabiosifolia Link
por: Sun, Shikai, et al.
Publicado: (2021)

Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma
por: Pan, Botao, et al.
Publicado: (2021)

Antifungal mode of action of macrocarpal C extracted from Eucalyptus globulus Labill (Lan An) towards the dermatophyte Trichophyton mentagrophytes
por: Wong, Jack Ho, et al.
Publicado: (2015)

The complete chloroplast genome sequence of Patrinia monandra: a traditional Chinese medicinal herb
por: Wang, Xinhong, et al.
Publicado: (2022)

Saussureae Involucratae Herba (Snow Lotus): Review of Chemical Compositions and Pharmacological Properties
por: Gong, Guowei, et al.
Publicado: (2020)

Network Pharmacology-Based Investigation of the Mechanism of Action of Plantaginis Herba in Hyperuricemia Treatment
por: Tang, Rong, et al.
Publicado: (2021)

The phytochemistry, pharmacology and traditional medicinal use of Glechomae Herba – a systematic review
por: Yang, Liu, et al.
Publicado: (2021)

Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling
por: Zhou, Xunian, et al.
Publicado: (2016)

In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
por: Ko, Chun-Hay, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1607va4nurnbikm7qli6hjlk28