Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors

A focused series of substituted 4H-1,2,6-thiadiazin-4-ones was designed and synthesized to probe the anti-cancer properties of this scaffold. Insights from previous kinase inhibitor programs were used to carefully select several different substitution patterns. Compounds were tested on bladder, pros...

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Detalles Bibliográficos
Autores principales: Kalogirou, Andreas S., East, Michael P., Laitinen, Tuomo, Torrice, Chad D., Maffuid, Kaitlyn A., Drewry, David H., Koutentis, Panayiotis A., Johnson, Gary L., Crona, Daniel J., Asquith, Christopher R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513058/
https://www.ncbi.nlm.nih.gov/pubmed/34641454
http://dx.doi.org/10.3390/molecules26195911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513058/
https://www.ncbi.nlm.nih.gov/pubmed/34641454
http://dx.doi.org/10.3390/molecules26195911

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