Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats

BACKGROUND: Hypoxic–ischemic encephalopathy (HIE) is a severe anoxic brain injury that leads to premature mortality or long-term disabilities in infants. Neuroinflammation is a vital contributor to the pathogenic cascade post-HIE and a mediator to secondary neuronal death. As a plasma membrane G-pro...

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Detalles Bibliográficos
Autores principales: Xie, Shucai, Jiang, Xili, Doycheva, Desislava Met, Shi, Hui, Jin, Peng, Gao, Ling, Liu, Rui, Xiao, Jie, Hu, Xiao, Tang, Jiping, Zhang, Lina, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513331/
https://www.ncbi.nlm.nih.gov/pubmed/34645465
http://dx.doi.org/10.1186/s12974-021-02289-7

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