Cargando…

Early phase clinical studies of AR‐42, a histone deacetylase inhibitor, for neurofibromatosis type 2‐associated vestibular schwannomas and meningiomas

OBJECTIVES: Two pilot studies of AR‐42, a pan‐histone deacetylase inhibitor, in human neurofibromatosis type 2 (NF2), vestibular schwannomas (VS), and meningiomas are presented. Primary endpoints included safety, and intra‐tumoral pharmacokinetics (PK) and pharmacodynamics (PD). METHODS: Pilot 1 is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Welling, D. Bradley, Collier, Katharine A., Burns, Sarah S., Oblinger, Janet L., Shu, Edina, Miles‐Markley, Beth A., Hofmeister, Craig C., Makary, Mina S., Slone, H. Wayne, Blakeley, Jaishri O., Mansouri, S. Alireza, Neff, Brian A., Jackler, Robert K., Mortazavi, Amir, Chang, Long‐Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Head and Neck, and Tumor Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513424/ https://www.ncbi.nlm.nih.gov/pubmed/34667843 http://dx.doi.org/10.1002/lio2.643

Ejemplares similares

Testimony by otolaryngologists in defense of tobacco companies 2009–2014
por: Jackler, Robert K.
Publicado: (2015)

Extracranial head and neck schwannomas: a study of the nerve of origin
por: Liu, Hin-Lun, et al.
Publicado: (2011)

Evaluation of MR imaging findings differentiating cavernous haemangiomas from schwannomas in the orbit
por: Xian, Junfang, et al.
Publicado: (2010)

Diffusion-weighted imaging in extracranial head and neck schwannomas: A distinctive appearance
por: Das, Abanti, et al.
Publicado: (2016)

Schwannoma of the ansa cervicalis
por: Okonkwo, O, et al.
Publicado: (2011)

The rising incidence of parotid metastases: our experience from four decades of parotid gland surgery
por: Franzen, A., et al.
Publicado: (2017)

Evaluation of three-dimensional mandibular movements after reconstruction with free fibula flap
por: BOLZONI, A., et al.
Publicado: (2015)

Spinal accessory nerve preservation in modified neck dissections: surgical and functional outcomes
por: Popovski, V., et al.
Publicado: (2017)

Non-curative treatment of patients with oral tongue squamous-cell carcinoma
por: Mroueh, R., et al.
Publicado: (2019)

Design of a customised bridging mandibular prosthesis for complex reconstruction: a pilot study
por: Tarsitano, A., et al.
Publicado: (2017)

Tracheocutaneous fistula in patients undergoing supracricoid partial laryngectomy: the role of chronic aspiration
por: DE VIRGILIO, A., et al.
Publicado: (2015)

Association between the increase in incidence of papillary thyroid carcinoma in Crete and exposure to radioactive agents
por: Prokopakis, E. P., et al.
Publicado: (2018)

Stapler suture of the pharynx after total laryngectomy
por: DEDIVITIS, R.A., et al.
Publicado: (2014)

Free flap head and neck reconstruction in the elderly: what is the impact on quality of life?
por: FERRI, A., et al.
Publicado: (2019)

Association between malformation type, location and functional deficits in lymphatic malformations of the head and neck in children
por: Wiegand, Susanne, et al.
Publicado: (2023)

Long-term disease-free survival in surgically-resected oral tongue cancer: a 10-year retrospective study
por: MARRA, A., et al.
Publicado: (2019)

PET-MRI in the head and neck area: challenges and new directions
por: Castelijns, J. A.
Publicado: (2011)

Pilot study on microvascular anastomosis: performance and future educational prospects
por: Berretti, G., et al.
Publicado: (2018)

Head and neck cancer in elderly patients: is microsurgical free-tissue transfer a safe procedure?
por: TARSITANO, A., et al.
Publicado: (2012)

Cervical paragangliomas: single centre experience with 44 cases
por: FERRANTE, A.M.R., et al.
Publicado: (2015)

Supracricoid partial laryngectomy with crico-hyoido-epiglottopexy for glottic carcinoma with anterior commissure involvement
por: Atallah, I., et al.
Publicado: (2017)

Salvage total laryngectomy after conservation laryngeal surgery for recurrent laryngeal squamous cell carcinoma
por: De Virgilio, A., et al.
Publicado: (2016)

Post-operative pain management in head and neck cancer patients: predictive factors and efficacy of therapy
por: Bianchini, C., et al.
Publicado: (2016)

Surgical nodal management in hypopharyngeal and laryngeal cancer
por: Ketterer, M. C., et al.
Publicado: (2020)

Role of steroids in conservative treatment of parapharyngeal and retropharyngeal abscess in children
por: Villanueva-Fernández, Eva, et al.
Publicado: (2022)

Indications of cone beam CT in head and neck imaging in children
por: Walliczek-Dworschak, U., et al.
Publicado: (2017)

Head and neck reconstruction with pedicled flaps in the free flap era
por: Mahieu, R., et al.
Publicado: (2016)

The predictive and prognostic value of low skeletal muscle mass for dose-limiting toxicity and survival in head and neck cancer patients receiving concomitant cetuximab and radiotherapy
por: Huiskamp, L. F. J., et al.
Publicado: (2020)

Supratracheal laryngectomy: current indications and contraindications
por: SUCCO, G., et al.
Publicado: (2015)

Is there a role for postoperative radiotherapy following open partial laryngectomy when prognostic factors on the pathological specimen are unfavourable? A survey of head and neck surgical/radiation oncologists
por: RUSSI, E.G., et al.
Publicado: (2013)

Low skeletal muscle mass predicts frailty in elderly head and neck cancer patients
por: Meerkerk, C. D. A., et al.
Publicado: (2021)

Zenker’s diverticulum: Rotterdam experience
por: Visser, L. J., et al.
Publicado: (2015)

Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study
por: Rogers, S. N., et al.
Publicado: (2020)

The relation between hypoxia and proliferation biomarkers with radiosensitivity in locally advanced laryngeal cancer
por: van den Bovenkamp, Karlijn, et al.
Publicado: (2023)

Surgical complications in orbital decompression for Graves' orbitopathy
por: Sellari-Franceschini, S., et al.
Publicado: (2016)

High DNMT1 Is Associated With Worse Local Control in Early‐Stage Laryngeal Squamous Cell Carcinoma
por: Bruine de Bruin, Leonie, et al.
Publicado: (2021)

Oncological outcome of vocal cord-only radiotherapy for cT1-T2 glottic laryngeal squamous cell carcinoma
por: de Ridder, Mischa, et al.
Publicado: (2023)

Parapharyngeal space tumours: video-assisted minimally invasive transcervical approach
por: Pilolli, F., et al.
Publicado: (2016)

Doppler ultrasonography before thyroidectomy is not useful to prevent cerebrovascular accident
por: RAFFAELLI, M., et al.
Publicado: (2015)

A miRNA signature suggestive of nodal metastases from laryngeal carcinoma
por: Ricciardiello, F., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qkfoflngbb54frs88a3u7o3s0i