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Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease
Repurposing FDA-approved inhibitors able to prevent infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could provide a rapid path to establish new therapeutic options to mitigate the effects of coronavirus disease 2019 (COVID-19). Proteolytic cleavages of the spike (S) protein...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513479/ https://www.ncbi.nlm.nih.gov/pubmed/34406858 http://dx.doi.org/10.1128/JVI.00975-21 |
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por Kreutzberger, Alex J.B., Sanyal, Anwesha, Ojha, Ravi, Pyle, Jesse D., Vapalahti, Olli, Balistreri, Giuseppe, Kirchhausen, Tom
Publicado 2021
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Publicado 2021
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Online
Artículo
Texto