Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength

Birth defects result from interactions between genetic and environmental factors, but the mechanisms remain poorly understood. We find that mutations and teratogens interact in predictable ways to cause birth defects by changing target cell sensitivity to Hedgehog (Hh) ligands. These interactions co...

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Detalles Bibliográficos
Autores principales: Kong, Jennifer H., Young, Cullen B., Pusapati, Ganesh V., Espinoza, F. Hernán, Patel, Chandni B., Beckert, Francis, Ho, Sebastian, Patel, Bhaven B., Gabriel, George C., Aravind, L., Bazan, J. Fernando, Gunn, Teresa M., Lo, Cecilia W., Rohatgi, Rajat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513608/
https://www.ncbi.nlm.nih.gov/pubmed/34486668
http://dx.doi.org/10.1242/dev.199867

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