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Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the huntingtin gene (HTT). Although HD has been shown to have a developmental component, how early during human embryogenesis the HTT-CAG expansion can cause embryonic defects remains un...

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Detalles Bibliográficos
Autores principales:	Galgoczi, Szilvia, Ruzo, Albert, Markopoulos, Christian, Yoney, Anna, Phan-Everson, Tien, Li, Shu, Haremaki, Tomomi, Metzger, Jakob J., Etoc, Fred, Brivanlou, Ali H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2021
Materias:	Human Development
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513611/ https://www.ncbi.nlm.nih.gov/pubmed/34608934 http://dx.doi.org/10.1242/dev.199513

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