Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all an...

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Detalles Bibliográficos
Autores principales: Mc Gann, Patrick, Geringer, Matthew R., Hall, Lindsey R., Lebreton, Francois, Markelz, Elizabeth, Kwak, Yoon I., Johnson, Sheila, Ong, Ana C., Powell, Aubrey, Tekle, Tsigereda, Bergman, Yehudit, Simner, Patricia J., Bennett, Jason W., Cybulski, Robert J., White, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2021
Materias:
Antimicrobial Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513626/
https://www.ncbi.nlm.nih.gov/pubmed/34448689
http://dx.doi.org/10.1099/jmm.0.001406
Descripción
Sumario:Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase bla (NDM-1), the extended-spectrum β-lactamase bla (PER-1), and the rare 16S methyltransferase rmtB2.

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