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GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice
Skeletal muscle insulin resistance is a main defect in type 2 diabetes (T2D), which is associated with impaired function and content of glucose transporter type 4 (GLUT4). GLUT4 overexpression in skeletal muscle tissue can improve glucose homeostasis. Therefore, we created an engineered muscle const...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514095/ https://www.ncbi.nlm.nih.gov/pubmed/34644106 http://dx.doi.org/10.1126/sciadv.abg3947 |