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Sirolimus and Other Mechanistic Target of Rapamycin Inhibitors Directly Activate Latent Pathogenic Human Polyomavirus Replication

BACKGROUND: Human polyomaviruses can reactivate in transplant patients, causing nephropathy, progressive multifocal leukoencephalopathy, Merkel cell carcinoma, pruritic, rash or trichodysplasia spinulosa. Sirolimus and related mechanistic target of rapamycin (mTOR) inhibitors are transplant immunosu...

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Detalles Bibliográficos
Autores principales:	Alvarez Orellana, Jennifer, Kwun, Hyun Jin, Artusi, Sara, Chang, Yuan, Moore, Patrick S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514189/ https://www.ncbi.nlm.nih.gov/pubmed/32060513 http://dx.doi.org/10.1093/infdis/jiaa071

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