Introducing physical exercise as a potential strategy in liver cancer prevention and development

AIM: This study aimed to investigate the anticancer properties of physical activity by network analysis in trained rats. BACKGROUND: Much evidence supports the benefits of physical activity, most of which are related to metabolism regulation and body health. Deeper investigation deals with other features of physical activity, such as its anticancer properties METHODS: Protein-protein interaction network analysis was applied to investigate the proteome profile of livers of rats subjected to physical activity through bioinformatics. Twelve differentially expressed proteins were searched and analyzed by Cytoscape 3.7.2 and its plug-ins. The network was analyzed to identify hub-bottleneck nodes. An action map was constructed for the central proteins. RESULTS: Among the queried proteins, Eno1 and Pgm1 were only assigned as hubs by Network Analzyer. Gpi, Pkm, Aldoa, and Aldoart2 were identified as central nodes among the first neighbors of network elements. Furthermore, the glycolytic, carbohydrate catabolic, and glucose metabolic processes are key elements that could be imperative in the mechanism of exercise in liver function. The anticancer properties of the central nodes were highlighted. CONCLUSION: The network findings indicate the anticancer properties of physical activity, which has also been supported by previous investigations.