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Side effects of omeprazole: a system biology study

AIM: To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study. BACKGROUND: Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion. METHODS: Gene expression profiles of “human coronary artery endothelial cells” in the abs...

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Autores principales: Hamzeloo-Moghadam, Maryam, Rezaei Tavirani, Mostafa, Jahani-Sherafat, Somayeh, Rezaei Tavirani, Sina, Esmaeili, Somayeh, Ansari, Mojtaba, Ahmadzadeh, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514216/
https://www.ncbi.nlm.nih.gov/pubmed/34659661
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author Hamzeloo-Moghadam, Maryam
Rezaei Tavirani, Mostafa
Jahani-Sherafat, Somayeh
Rezaei Tavirani, Sina
Esmaeili, Somayeh
Ansari, Mojtaba
Ahmadzadeh, Alireza
author_facet Hamzeloo-Moghadam, Maryam
Rezaei Tavirani, Mostafa
Jahani-Sherafat, Somayeh
Rezaei Tavirani, Sina
Esmaeili, Somayeh
Ansari, Mojtaba
Ahmadzadeh, Alireza
author_sort Hamzeloo-Moghadam, Maryam
collection PubMed
description AIM: To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study. BACKGROUND: Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion. METHODS: Gene expression profiles of “human coronary artery endothelial cells” in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings. RESULTS: Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole. CONCLUSION: In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required.
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spelling pubmed-85142162021-10-15 Side effects of omeprazole: a system biology study Hamzeloo-Moghadam, Maryam Rezaei Tavirani, Mostafa Jahani-Sherafat, Somayeh Rezaei Tavirani, Sina Esmaeili, Somayeh Ansari, Mojtaba Ahmadzadeh, Alireza Gastroenterol Hepatol Bed Bench Original Article AIM: To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study. BACKGROUND: Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion. METHODS: Gene expression profiles of “human coronary artery endothelial cells” in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings. RESULTS: Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole. CONCLUSION: In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required. Shaheed Beheshti University of Medical Sciences 2021 /pmc/articles/PMC8514216/ /pubmed/34659661 Text en ©2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hamzeloo-Moghadam, Maryam
Rezaei Tavirani, Mostafa
Jahani-Sherafat, Somayeh
Rezaei Tavirani, Sina
Esmaeili, Somayeh
Ansari, Mojtaba
Ahmadzadeh, Alireza
Side effects of omeprazole: a system biology study
title Side effects of omeprazole: a system biology study
title_full Side effects of omeprazole: a system biology study
title_fullStr Side effects of omeprazole: a system biology study
title_full_unstemmed Side effects of omeprazole: a system biology study
title_short Side effects of omeprazole: a system biology study
title_sort side effects of omeprazole: a system biology study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514216/
https://www.ncbi.nlm.nih.gov/pubmed/34659661
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