Cargando…
Side effects of omeprazole: a system biology study
AIM: To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study. BACKGROUND: Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion. METHODS: Gene expression profiles of “human coronary artery endothelial cells” in the abs...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514216/ https://www.ncbi.nlm.nih.gov/pubmed/34659661 |
_version_ | 1784583341085818880 |
---|---|
author | Hamzeloo-Moghadam, Maryam Rezaei Tavirani, Mostafa Jahani-Sherafat, Somayeh Rezaei Tavirani, Sina Esmaeili, Somayeh Ansari, Mojtaba Ahmadzadeh, Alireza |
author_facet | Hamzeloo-Moghadam, Maryam Rezaei Tavirani, Mostafa Jahani-Sherafat, Somayeh Rezaei Tavirani, Sina Esmaeili, Somayeh Ansari, Mojtaba Ahmadzadeh, Alireza |
author_sort | Hamzeloo-Moghadam, Maryam |
collection | PubMed |
description | AIM: To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study. BACKGROUND: Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion. METHODS: Gene expression profiles of “human coronary artery endothelial cells” in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings. RESULTS: Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole. CONCLUSION: In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required. |
format | Online Article Text |
id | pubmed-8514216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-85142162021-10-15 Side effects of omeprazole: a system biology study Hamzeloo-Moghadam, Maryam Rezaei Tavirani, Mostafa Jahani-Sherafat, Somayeh Rezaei Tavirani, Sina Esmaeili, Somayeh Ansari, Mojtaba Ahmadzadeh, Alireza Gastroenterol Hepatol Bed Bench Original Article AIM: To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study. BACKGROUND: Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion. METHODS: Gene expression profiles of “human coronary artery endothelial cells” in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings. RESULTS: Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole. CONCLUSION: In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required. Shaheed Beheshti University of Medical Sciences 2021 /pmc/articles/PMC8514216/ /pubmed/34659661 Text en ©2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hamzeloo-Moghadam, Maryam Rezaei Tavirani, Mostafa Jahani-Sherafat, Somayeh Rezaei Tavirani, Sina Esmaeili, Somayeh Ansari, Mojtaba Ahmadzadeh, Alireza Side effects of omeprazole: a system biology study |
title | Side effects of omeprazole: a system biology study |
title_full | Side effects of omeprazole: a system biology study |
title_fullStr | Side effects of omeprazole: a system biology study |
title_full_unstemmed | Side effects of omeprazole: a system biology study |
title_short | Side effects of omeprazole: a system biology study |
title_sort | side effects of omeprazole: a system biology study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514216/ https://www.ncbi.nlm.nih.gov/pubmed/34659661 |
work_keys_str_mv | AT hamzeloomoghadammaryam sideeffectsofomeprazoleasystembiologystudy AT rezaeitaviranimostafa sideeffectsofomeprazoleasystembiologystudy AT jahanisherafatsomayeh sideeffectsofomeprazoleasystembiologystudy AT rezaeitaviranisina sideeffectsofomeprazoleasystembiologystudy AT esmaeilisomayeh sideeffectsofomeprazoleasystembiologystudy AT ansarimojtaba sideeffectsofomeprazoleasystembiologystudy AT ahmadzadehalireza sideeffectsofomeprazoleasystembiologystudy |