The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

Astrocytes are essential cells of the central nervous system, characterized by dynamic relationships with neurons that range from functional metabolic interactions and regulation of neuronal firing activities, to the release of neurotrophic and neuroprotective factors. In Parkinson’s disease (PD), d...

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Detalles Bibliográficos
Autores principales: de Rus Jacquet, Aurelie, Tancredi, Jenna L, Lemire, Andrew L, DeSantis, Michael C, Li, Wei-Ping, O'Shea, Erin K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514240/
https://www.ncbi.nlm.nih.gov/pubmed/34590578
http://dx.doi.org/10.7554/eLife.73062

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