The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila

PERK is an endoplasmic reticulum (ER) transmembrane sensor that phosphorylates eIF2α to initiate the Unfolded Protein Response (UPR). eIF2α phosphorylation promotes stress-responsive gene expression most notably through the transcription factor ATF4 that contains a regulatory 5’ leader. Possible PER...

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Detalles Bibliográficos
Autores principales: Brown, Brian, Mitra, Sahana, Roach, Finnegan D, Vasudevan, Deepika, Ryoo, Hyung Don
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514241/
https://www.ncbi.nlm.nih.gov/pubmed/34605405
http://dx.doi.org/10.7554/eLife.74047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514241/
https://www.ncbi.nlm.nih.gov/pubmed/34605405
http://dx.doi.org/10.7554/eLife.74047

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