PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones

The reticulon-3 (RTN3)-driven targeting complex promotes clearance of misfolded prohormones from the endoplasmic reticulum (ER) for lysosomal destruction by ER-phagy. Because RTN3 resides in the cytosolic leaflet of the ER bilayer, the mechanism of selecting misfolded prohormones as ER-phagy cargo o...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Jie, Knupp, Jeffrey, Arunagiri, Anoop, Haataja, Leena, Arvan, Peter, Tsai, Billy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514460/
https://www.ncbi.nlm.nih.gov/pubmed/34645803
http://dx.doi.org/10.1038/s41467-021-26225-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514460/
https://www.ncbi.nlm.nih.gov/pubmed/34645803
http://dx.doi.org/10.1038/s41467-021-26225-8

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