Cargando…
Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults
Identifying how socioeconomic positioning and genetic factors interact in the development of obesity is imperative for population-level obesity prevention strategies. The current study investigated whether social positioning, either independently or through interaction with a polygenic score for Bod...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514538/ https://www.ncbi.nlm.nih.gov/pubmed/34645866 http://dx.doi.org/10.1038/s41598-021-99332-7 |
_version_ | 1784583413560246272 |
---|---|
author | Tommerup, Kristiane Ajnakina, Olesya Steptoe, Andrew |
author_facet | Tommerup, Kristiane Ajnakina, Olesya Steptoe, Andrew |
author_sort | Tommerup, Kristiane |
collection | PubMed |
description | Identifying how socioeconomic positioning and genetic factors interact in the development of obesity is imperative for population-level obesity prevention strategies. The current study investigated whether social positioning, either independently or through interaction with a polygenic score for Body Mass Index (BMI-PGS), influences BMI trajectories across older adulthood. Data were analysed from 7,183 individuals from the English Longitudinal Study of Aging (ELSA). Interactions between the BMI-PGS and; lower educational attainment, self-perceived social status (SSS), and income, on BMI trajectories over 12 years across older adulthood were investigated through linear mixed effects models. Lower educational attainment, SSS and income were each associated with a higher baseline BMI for women, but not for men. There were interaction effects between BMI-PGS and social positioning such that men aged > 65 with a lower educational attainment (β = 0.62; 95%CI 0.00 – 1.24, p < 0.05), men aged ≤ 65 of a lower income (β = − 0.72, 95%CI − 1.21 - − 0.23, p < 0.01) and women aged ≤ 65 of lower SSS (β = − 1.41; 95%CI − 2.46 – 0.36, p < 0.01) showed stronger associations between the BMI-PGS and baseline BMI. There were few associations between markers of socioeconomic position and rate of change in BMI over the follow-up period. In sum, lower socioeconomic positioning showed adverse associations with women’s BMI in older adulthood. Moreover, the expression of the BMI-PGS, or extent to which it translates to a higher BMI, was subtly influenced by socioeconomic standing in both women and in men. |
format | Online Article Text |
id | pubmed-8514538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85145382021-10-14 Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults Tommerup, Kristiane Ajnakina, Olesya Steptoe, Andrew Sci Rep Article Identifying how socioeconomic positioning and genetic factors interact in the development of obesity is imperative for population-level obesity prevention strategies. The current study investigated whether social positioning, either independently or through interaction with a polygenic score for Body Mass Index (BMI-PGS), influences BMI trajectories across older adulthood. Data were analysed from 7,183 individuals from the English Longitudinal Study of Aging (ELSA). Interactions between the BMI-PGS and; lower educational attainment, self-perceived social status (SSS), and income, on BMI trajectories over 12 years across older adulthood were investigated through linear mixed effects models. Lower educational attainment, SSS and income were each associated with a higher baseline BMI for women, but not for men. There were interaction effects between BMI-PGS and social positioning such that men aged > 65 with a lower educational attainment (β = 0.62; 95%CI 0.00 – 1.24, p < 0.05), men aged ≤ 65 of a lower income (β = − 0.72, 95%CI − 1.21 - − 0.23, p < 0.01) and women aged ≤ 65 of lower SSS (β = − 1.41; 95%CI − 2.46 – 0.36, p < 0.01) showed stronger associations between the BMI-PGS and baseline BMI. There were few associations between markers of socioeconomic position and rate of change in BMI over the follow-up period. In sum, lower socioeconomic positioning showed adverse associations with women’s BMI in older adulthood. Moreover, the expression of the BMI-PGS, or extent to which it translates to a higher BMI, was subtly influenced by socioeconomic standing in both women and in men. Nature Publishing Group UK 2021-10-13 /pmc/articles/PMC8514538/ /pubmed/34645866 http://dx.doi.org/10.1038/s41598-021-99332-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Tommerup, Kristiane Ajnakina, Olesya Steptoe, Andrew Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults |
title | Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults |
title_full | Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults |
title_fullStr | Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults |
title_full_unstemmed | Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults |
title_short | Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults |
title_sort | genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514538/ https://www.ncbi.nlm.nih.gov/pubmed/34645866 http://dx.doi.org/10.1038/s41598-021-99332-7 |
work_keys_str_mv | AT tommerupkristiane geneticpropensityforobesitysocioeconomicpositionandtrajectoriesofbodymassindexinolderadults AT ajnakinaolesya geneticpropensityforobesitysocioeconomicpositionandtrajectoriesofbodymassindexinolderadults AT steptoeandrew geneticpropensityforobesitysocioeconomicpositionandtrajectoriesofbodymassindexinolderadults |