Cargando…

Quantitative Description of Surface Complementarity of Antibody-Antigen Interfaces

Antibodies have the remarkable ability to recognise their cognate antigens with extraordinary affinity and specificity. Discerning the rules that define antibody-antigen recognition is a fundamental step in the rational design and engineering of functional antibodies with desired properties. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Rienzo, Lorenzo, Milanetti, Edoardo, Ruocco, Giancarlo, Lepore, Rosalba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514621/ https://www.ncbi.nlm.nih.gov/pubmed/34660699 http://dx.doi.org/10.3389/fmolb.2021.749784

Ejemplares similares

Shape Complementarity Optimization of Antibody–Antigen Interfaces: The Application to SARS-CoV-2 Spike Protein
por: De Lauro, Alfredo, et al.
Publicado: (2022)

Differences in the organization of interface residues tunes the stability of the SARS-CoV-2 spike-ACE2 complex
por: Miotto, Mattia, et al.
Publicado: (2023)

Characterizing Hydropathy of Amino Acid Side Chain in a Protein Environment by Investigating the Structural Changes of Water Molecules Network
por: Di Rienzo, Lorenzo, et al.
Publicado: (2021)

Molecular Mechanisms Behind Anti SARS-CoV-2 Action of Lactoferrin
por: Miotto, Mattia, et al.
Publicado: (2021)

Electrostatic complementarity at the interface drives transient protein-protein interactions
por: Grassmann, Greta, et al.
Publicado: (2023)

In-Silico Evidence for a Two Receptor Based Strategy of SARS-CoV-2
por: Milanetti, Edoardo, et al.
Publicado: (2021)

Quantitative Characterization of Binding Pockets and Binding Complementarity by Means of Zernike Descriptors
por: Di Rienzo, Lorenzo, et al.
Publicado: (2020)

Superposition-free comparison and clustering of antibody binding sites: implications for the prediction of the nature of their antigen
por: Di Rienzo, Lorenzo, et al.
Publicado: (2017)

Antibody-Antigen Binding Interface Analysis in the Big Data Era
por: Reis, Pedro B. P. S., et al.
Publicado: (2022)

A novel computational strategy for defining the minimal protein molecular surface representation
por: Grassmann, Greta, et al.
Publicado: (2022)

Computational structural-based GPCR optimization for user-defined ligand: Implications for the development of biosensors
por: Di Rienzo, Lorenzo, et al.
Publicado: (2023)

A novel strategy for molecular interfaces optimization: The case of Ferritin-Transferrin receptor interaction
por: Di Rienzo, Lorenzo, et al.
Publicado: (2020)

Quantitative comparison of protein-protein interaction interface using physicochemical feature-based descriptors of surface patches
por: Shin, Woong-Hee, et al.
Publicado: (2023)

Understanding the complementarity and plasticity of antibody–antigen interfaces
por: Myung, Yoochan, et al.
Publicado: (2023)

Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats
por: Fernández-Quintero, Monica L., et al.
Publicado: (2022)

Exploring the Association Between Sialic Acid and SARS-CoV-2 Spike Protein Through a Molecular Dynamics-Based Approach
por: Bò, Leonardo, et al.
Publicado: (2021)

Does blood type affect the COVID-19 infection pattern?
por: Miotto, Mattia, et al.
Publicado: (2021)

Spatial organization of hydrophobic and charged residues affects protein thermal stability and binding affinity
por: Desantis, Fausta, et al.
Publicado: (2022)

Investigating the competition between ACE2 natural molecular interactors and SARS-CoV-2 candidate inhibitors
por: Milanetti, Edoardo, et al.
Publicado: (2023)

Corrigendum: Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats
por: Fernández-Quintero, Monica L., et al.
Publicado: (2022)

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020)

Binding site identification of G protein-coupled receptors through a 3D Zernike polynomials-based method: application to C. elegans olfactory receptors
por: Di Rienzo, Lorenzo, et al.
Publicado: (2022)

Learned features of antibody-antigen binding affinity
por: Miller, Nathaniel L., et al.
Publicado: (2023)

2D Zernike polynomial expansion: Finding the protein-protein binding regions
por: Milanetti, Edoardo, et al.
Publicado: (2020)

Thermometer: a webserver to predict protein thermal stability
por: Miotto, Mattia, et al.
Publicado: (2022)

Production and characterization of monoclonal antibodies for the detection of the hepatitis C core antigen
por: Vidal-Alcántara, Erick Joan, et al.
Publicado: (2023)

Immuno-dominant dengue NS1 peptides as antigens for production of monoclonal antibodies
por: Munasinghe, Erandi, et al.
Publicado: (2022)

Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition
por: Di Rienzo, Lorenzo, et al.
Publicado: (2021)

Antigen–Antibody Complex-Guided Exploration of the Hotspots Conferring the Immune-Escaping Ability of the SARS-CoV-2 RBD
por: Fung, Kit-Man, et al.
Publicado: (2022)

Structural and Biophysical Investigation of the Key Hotspots on the Surface of Epstein–Barr Nuclear Antigen 1 Essential for DNA Recognition and Pathogenesis
por: Hashmi, Huma Farooque, et al.
Publicado: (2021)

Insights on protein thermal stability: a graph representation of molecular interactions
por: Miotto, Mattia, et al.
Publicado: (2019)

Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface
por: Yu, Chung-Ming, et al.
Publicado: (2012)

A Review of Methodologies for the Detection, Quantitation, and Localization of Free Cysteine in Recombinant Proteins: A Focus on Therapeutic Monoclonal Antibodies
por: Metcalfe, Clive
Publicado: (2022)

Editorial: Protein-Material Interfaces: Fundamentals and Applications
por: Asuri, Prashanth, et al.
Publicado: (2022)

Antibody production and tolerance to the α-gal epitope as models for understanding and preventing the immune response to incompatible ABO carbohydrate antigens and for α-gal therapies
por: Galili, Uri
Publicado: (2023)

Editorial: Protein-Material interfaces: Fundamentals and applications volume II
por: Faccio, Greta, et al.
Publicado: (2023)

Helminth Glycans at the Host-Parasite Interface and Their Potential for Developing Novel Therapeutics
por: Bunte, Myrna J. M., et al.
Publicado: (2022)

ProDFace: A web-tool for the dissection of protein-DNA interfaces
por: Pal, Arumay, et al.
Publicado: (2022)

Quantitative Cryo-Electron Tomography
por: Navarro, Paula P.
Publicado: (2022)

Lipid/water interface of galactolipid bilayers in different lyotropic liquid-crystalline phases
por: Hryc, Jakub, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9d19u9b0fc6psf0u1ge0unl9pj