Cargando…

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH. How these signals affect the gating of these channels is the subject of intense research. We have previously identified a cytoplas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choveau, Frank S, Ben Soussia, Ismail, Bichet, Delphine, Franck, Chatelain C., Feliciangeli, Sylvain, Lesage, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514629/ https://www.ncbi.nlm.nih.gov/pubmed/34658895 http://dx.doi.org/10.3389/fphar.2021.755826

Ejemplares similares

Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels
por: Choveau, Frank S., et al.
Publicado: (2021)

Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels
por: Soussia, Ismail Ben, et al.
Publicado: (2018)

Alkaline-sensitive two-pore domain potassium channels form functional heteromers in pancreatic β-cells
por: Khoubza, Lamyaa, et al.
Publicado: (2022)

2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2)
por: Beltrán, Leopoldo, et al.
Publicado: (2013)

TREK-TRAAK two-pore domain potassium channels protect human retinal pigment epithelium cells from oxidative stress
por: Huang, Hao, et al.
Publicado: (2018)

Characterization of temperature-sensitive leak K(+) currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats
por: Viatchenko-Karpinski, Viacheslav, et al.
Publicado: (2018)

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels
por: Ben Soussia, Ismail, et al.
Publicado: (2019)

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel
por: Brohawn, Stephen G., et al.
Publicado: (2014)

Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1
por: Schmidpeter, Philipp A. M., et al.
Publicado: (2023)

Deletion of TRAAK Potassium Channel Affects Brain Metabolism and Protects against Ischemia
por: Laigle, Christophe, et al.
Publicado: (2012)

Of transporter design, screening for gating modifiers, and how TRAAK gates
por: Adler, Elizabeth M.
Publicado: (2015)

Behavioral characterization of mice lacking Trek channels
por: Mirkovic, Kelsey, et al.
Publicado: (2012)

Conduction and Gating Properties of the TRAAK Channel from Molecular Dynamics Simulations with Different Force Fields
por: Ocello, Riccardo, et al.
Publicado: (2020)

The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier
por: Brohawn, Stephen G, et al.
Publicado: (2019)

Selective regulation of human TRAAK channels by biologically active phospholipids
por: Schrecke, Samantha, et al.
Publicado: (2020)

Ultrasound activates mechanosensitive TRAAK K(+) channels through the lipid membrane
por: Sorum, Ben, et al.
Publicado: (2021)

Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2
por: Zhuo, Ren-Gong, et al.
Publicado: (2016)

Energetic differences between non-domain-swapped and domain-swapped chain connectivities in the K2P potassium channel TRAAK
por: Navarro-Retamal, Carlos, et al.
Publicado: (2018)

Recombinant tandem of pore-domains in a Weakly Inward rectifying K(+) channel 2 (TWIK2) forms active lysosomal channels
por: Bobak, Nicole, et al.
Publicado: (2017)

Activation of TREK-1, but Not TREK-2, Channel by Mood Stabilizers
por: Kim, Eun-Jin, et al.
Publicado: (2017)

The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels
por: Cunningham, Kevin P., et al.
Publicado: (2021)

Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer
por: Zhang, Gui-Ming, et al.
Publicado: (2015)

Are TREK Channels Temperature Sensors?
por: Rueda-Ruzafa, Lola, et al.
Publicado: (2021)

Effects of ionic strength on gating and permeation of TREK-2 K2P channels
por: Conrad, Linus J., et al.
Publicado: (2021)

Pressure and ultrasound activate mechanosensitive TRAAK K(+) channels through increased membrane tension
por: Sorum, Ben, et al.
Publicado: (2023)

Genetic Deletion of TREK-1 or TWIK-1/TREK-1 Potassium Channels does not Alter the Basic Electrophysiological Properties of Mature Hippocampal Astrocytes In Situ
por: Du, Yixing, et al.
Publicado: (2016)

Bepridil, a class IV antiarrhythmic agent, can block the TREK-1 potassium channel
por: Wang, Ying, et al.
Publicado: (2021)

Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters
por: Matamoros, Marcos, et al.
Publicado: (2023)

Up-Regulation of TREK-2 Potassium Channels in Cultured Astrocytes Requires De Novo Protein Synthesis: Relevance to Localization of TREK-2 Channels in Astrocytes after Transient Cerebral Ischemia
por: Rivera-Pagán, Aixa F., et al.
Publicado: (2015)

Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains
por: Bagriantsev, Sviatoslav N, et al.
Publicado: (2012)

Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the “spadin” Antidepressant
por: Vallée, Nicolas, et al.
Publicado: (2016)

Progesterone inhibits contraction and increases TREK-1 potassium channel expression in late pregnant rat uterus
por: Yin, Zongzhi, et al.
Publicado: (2017)

POPDC1 scaffolds a complex of adenylyl cyclase 9 and the potassium channel TREK‐1 in heart
por: Baldwin, Tanya A, et al.
Publicado: (2022)

Ion Channels and Thermosensitivity: TRP, TREK, or Both?
por: Lamas, J. Antonio, et al.
Publicado: (2019)

The 2-Pore Domain Potassium Channel TREK-1 Regulates Stretch-Induced Detachment of Alveolar Epithelial Cells
por: Roan, Esra, et al.
Publicado: (2014)

‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel
por: Zhang, Qiansen, et al.
Publicado: (2022)

Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice
por: Fang, Yongkang, et al.
Publicado: (2019)

Lipid-dependent gating of a voltage-gated potassium channel
por: Zheng, Hui, et al.
Publicado: (2011)

TREK channel activation suppresses migraine pain phenotype
por: Ávalos Prado, Pablo, et al.
Publicado: (2021)

TREK channels in Mechanotransduction: a Focus on the Cardiovascular System
por: Herrera-Pérez, Salvador, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_52jsh1r6acj60na381660bbi4a