Cargando…

Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer’s Disease in Amyloid Precursor Protein/Presenilin 1 Mice

Increasing evidence has shown a correlation between chronic periodontitis (CP) and Alzheimer’s disease (AD). Nevertheless, there is still a lack of direct evidence, and especially key molecules to connect the two diseases. This study aims to investigate potential protein links between CP and AD with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Qing, Fang, Qin, Zhou, Xincai, Yang, Hongfa, Dou, Yang, Zhang, Wenhao, Gong, Pu, Rong, Xianfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514664/ https://www.ncbi.nlm.nih.gov/pubmed/34658785 http://dx.doi.org/10.3389/fnmol.2021.728184

Ejemplares similares

Chronic Periodontitis and Alzheimer Disease: A Putative Link of Serum Proteins Identification by 2D-DIGE Proteomics
por: Rong, Xianfang, et al.
Publicado: (2020)

Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling
por: Nizzari, Mario, et al.
Publicado: (2012)

Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in β-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice
por: Xu, Xia, et al.
Publicado: (2022)

Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
por: Weggen, Sascha, et al.
Publicado: (2012)

Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin
por: Stemmer, Nina, et al.
Publicado: (2013)

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
por: Do, Hung N., et al.
Publicado: (2023)

Nicotinamide Reduces Amyloid Precursor Protein and Presenilin 1 in Brain Tissues of Amyloid Beta-Tail Vein Injected Mice
por: Kim, Eun Jin, et al.
Publicado: (2017)

The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
por: Cupers, Philippe, et al.
Publicado: (2001)

Peptides of Presenilin-1 Bind the Amyloid Precursor Protein Ectodomain and Offer a Novel and Specific Therapeutic Approach to Reduce ß-Amyloid in Alzheimer’s Disease
por: Dewji, Nazneen N., et al.
Publicado: (2015)

Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein
por: Cho, Yoon Young, et al.
Publicado: (2019)

The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
por: Verdile, Giuseppe, et al.
Publicado: (2006)

Protein Predictive Modeling and Simulation of Mutations of Presenilin-1 Familial Alzheimer’s Disease on the Orthosteric Site
por: Soto-Ospina, Alejandro, et al.
Publicado: (2021)

Role of Cofilin in Alzheimer’s Disease
por: Wang, Qiang, et al.
Publicado: (2020)

Upregulation of PGC-1α expression by Alzheimer’s disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP
por: Robinson, Ari, et al.
Publicado: (2014)

Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease
por: Kishimoto, Yasushi, et al.
Publicado: (2017)

β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice
por: Ye, Jian-Ya, et al.
Publicado: (2020)

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production
por: Rezai-Zadeh, Kavon, et al.
Publicado: (2009)

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
por: Annaert, Wim G., et al.
Publicado: (1999)

Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage Amyloid Precursor Protein/Presenilin 1 Mice
por: Zhang, Zhiyuan, et al.
Publicado: (2016)

Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice
por: Chen, Bo-Wen, et al.
Publicado: (2021)

Parkin acts as a transcription factor modulating presenilin-1 and presenilin-2 promoter transactivations
por: Duplan, Eric, et al.
Publicado: (2013)

Ibuprofen Rescues Abnormalities in Periodontal Tissues in Conditional Presenilin 1 and Presenilin 2 Double Knockout Mice
por: Su, Jiansheng, et al.
Publicado: (2013)

Presenilins in Alzheimer’s disease and frontotemporal dementia
por: Shen, Jie
Publicado: (2012)

Function and dysfunction of presenilin in Alzheimer’s disease
por: Shen, Jie
Publicado: (2013)

Distinguishing Closely Related Amyloid Precursors Using an RNA Aptamer
por: Sarell, Claire J., et al.
Publicado: (2014)

Amyloid oligomers as on-pathway precursors or off-pathway competitors of fibrils
por: Muschol, Martin, et al.
Publicado: (2023)

Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention
por: Agca, Cansu, et al.
Publicado: (2016)

Pharmocologic treatment with histone deacetylase 6 inhibitor (ACY-738) recovers Alzheimer's disease phenotype in amyloid precursor protein/presenilin 1 (APP/PS1) mice
por: Majid, Tabassum, et al.
Publicado: (2015)

Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
por: Kamikubo, Yuji, et al.
Publicado: (2023)

Amyloid Precursor Protein and Alzheimer’s Disease
por: Orobets, Kseniia S., et al.
Publicado: (2023)

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation
por: Davis, Richard C, et al.
Publicado: (2011)

Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia
por: Ledo, Jose Henrique, et al.
Publicado: (2020)

Regulating amyloid precursor protein synthesis through an internal ribosomal entry site
por: Beaudoin, Monique E., et al.
Publicado: (2008)

APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder
por: Sokol, Deborah K., et al.
Publicado: (2023)

Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function
por: Parent, Angèle T., et al.
Publicado: (2010)

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
por: Raven, Frank, et al.
Publicado: (2017)

Retraction: An aberrant phosphorylation of amyloid precursor protein tyrosine regulates its trafficking and the binding to the clathrin endocytic complex in neural stem cells of Alzheimer's disease patients
Publicado: (2023)

Stress Elicits Contrasting Effects on Rac1-Cofilin Signaling in the Hippocampus and Amygdala
por: Bose, Mihika, et al.
Publicado: (2022)

A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1
por: Fitzjohn, Stephen M, et al.
Publicado: (2010)

Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs
por: Sato, Naoyuki, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_uo79tv35vfo7aflbq6sak4scoo