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hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors

Monopolar spindle-one binder (MOBs) proteins are evolutionarily conserved and contribute to various cellular signalling pathways. Recently, we reported that hMOB2 functions in preventing the accumulation of endogenous DNA damage and a subsequent p53/p21-dependent G1/S cell cycle arrest in untransfor...

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Detalles Bibliográficos
Autores principales:	Gundogdu, Ramazan, Erdogan, M. Kadir, Ditsiou, Angeliki, Spanswick, Victoria, Garcia-Gomez, Juan Jose, Hartley, John A., Esashi, Fumiko, Hergovich, Alexander, Gomez, Valenti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514680/ https://www.ncbi.nlm.nih.gov/pubmed/34363951 http://dx.doi.org/10.1016/j.cellsig.2021.110106

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