Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment

The tumor microenvironment (TME), which includes immune cells, fibroblasts, and other components, is the site of tumor cell growth and metastasis and significantly impacts tumor development. Among them, N6-methyladenosine RNA modifications (m6A RNA modifications) are the most abundant internal modif...

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Autores principales: Si, Chaohua, Chen, Chen, Guo, Yaxin, Kang, Qiaozhen, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514707/
https://www.ncbi.nlm.nih.gov/pubmed/34660577
http://dx.doi.org/10.3389/fcell.2021.711815
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author Si, Chaohua
Chen, Chen
Guo, Yaxin
Kang, Qiaozhen
Sun, Zhenqiang
author_facet Si, Chaohua
Chen, Chen
Guo, Yaxin
Kang, Qiaozhen
Sun, Zhenqiang
author_sort Si, Chaohua
collection PubMed
description The tumor microenvironment (TME), which includes immune cells, fibroblasts, and other components, is the site of tumor cell growth and metastasis and significantly impacts tumor development. Among them, N6-methyladenosine RNA modifications (m6A RNA modifications) are the most abundant internal modifications in coding and non-coding RNAs, which can significantly influence the cancer process and have potential as biomarkers and potential therapeutic targets for tumor therapy. This manuscript reviews the role of m6A RNA modifications in TME and their application in tumor therapy. To some extent, an in-depth understanding of the relationship between TME and m6A RNA modifications will provide new approaches and ideas for future cancer therapy.
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spelling pubmed-85147072021-10-15 Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment Si, Chaohua Chen, Chen Guo, Yaxin Kang, Qiaozhen Sun, Zhenqiang Front Cell Dev Biol Cell and Developmental Biology The tumor microenvironment (TME), which includes immune cells, fibroblasts, and other components, is the site of tumor cell growth and metastasis and significantly impacts tumor development. Among them, N6-methyladenosine RNA modifications (m6A RNA modifications) are the most abundant internal modifications in coding and non-coding RNAs, which can significantly influence the cancer process and have potential as biomarkers and potential therapeutic targets for tumor therapy. This manuscript reviews the role of m6A RNA modifications in TME and their application in tumor therapy. To some extent, an in-depth understanding of the relationship between TME and m6A RNA modifications will provide new approaches and ideas for future cancer therapy. Frontiers Media S.A. 2021-09-30 /pmc/articles/PMC8514707/ /pubmed/34660577 http://dx.doi.org/10.3389/fcell.2021.711815 Text en Copyright © 2021 Si, Chen, Guo, Kang and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Si, Chaohua
Chen, Chen
Guo, Yaxin
Kang, Qiaozhen
Sun, Zhenqiang
Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment
title Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment
title_full Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment
title_fullStr Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment
title_full_unstemmed Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment
title_short Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment
title_sort effect, mechanism, and applications of coding/non-coding rna m6a modification in tumor microenvironment
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514707/
https://www.ncbi.nlm.nih.gov/pubmed/34660577
http://dx.doi.org/10.3389/fcell.2021.711815
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