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Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism
Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis, transfer, and insertion into target proteins require many components. Mitochondrial ISC assembly is the foundation of all cellular ISCs in eukaryotic cells. The mitochondrial ISC cooperates with the cytosolic...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514734/ https://www.ncbi.nlm.nih.gov/pubmed/34660592 http://dx.doi.org/10.3389/fcell.2021.735678 |
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author | Shi, Ruifeng Hou, Wenya Wang, Zhao-Qi Xu, Xingzhi |
author_facet | Shi, Ruifeng Hou, Wenya Wang, Zhao-Qi Xu, Xingzhi |
author_sort | Shi, Ruifeng |
collection | PubMed |
description | Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis, transfer, and insertion into target proteins require many components. Mitochondrial ISC assembly is the foundation of all cellular ISCs in eukaryotic cells. The mitochondrial ISC cooperates with the cytosolic Fe/S protein assembly (CIA) systems to accomplish the cytosolic and nuclear Fe/S clusters maturation. ISCs are needed for diverse cellular functions, including nitrogen fixation, oxidative phosphorylation, mitochondrial respiratory pathways, and ribosome assembly. Recent research advances have confirmed the existence of different ISCs in enzymes that regulate DNA metabolism, including helicases, nucleases, primases, DNA polymerases, and glycosylases. Here we outline the synthesis of mitochondrial, cytosolic and nuclear ISCs and highlight their functions in DNA metabolism. |
format | Online Article Text |
id | pubmed-8514734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85147342021-10-15 Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism Shi, Ruifeng Hou, Wenya Wang, Zhao-Qi Xu, Xingzhi Front Cell Dev Biol Cell and Developmental Biology Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis, transfer, and insertion into target proteins require many components. Mitochondrial ISC assembly is the foundation of all cellular ISCs in eukaryotic cells. The mitochondrial ISC cooperates with the cytosolic Fe/S protein assembly (CIA) systems to accomplish the cytosolic and nuclear Fe/S clusters maturation. ISCs are needed for diverse cellular functions, including nitrogen fixation, oxidative phosphorylation, mitochondrial respiratory pathways, and ribosome assembly. Recent research advances have confirmed the existence of different ISCs in enzymes that regulate DNA metabolism, including helicases, nucleases, primases, DNA polymerases, and glycosylases. Here we outline the synthesis of mitochondrial, cytosolic and nuclear ISCs and highlight their functions in DNA metabolism. Frontiers Media S.A. 2021-09-30 /pmc/articles/PMC8514734/ /pubmed/34660592 http://dx.doi.org/10.3389/fcell.2021.735678 Text en Copyright © 2021 Shi, Hou, Wang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Shi, Ruifeng Hou, Wenya Wang, Zhao-Qi Xu, Xingzhi Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism |
title | Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism |
title_full | Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism |
title_fullStr | Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism |
title_full_unstemmed | Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism |
title_short | Biogenesis of Iron–Sulfur Clusters and Their Role in DNA Metabolism |
title_sort | biogenesis of iron–sulfur clusters and their role in dna metabolism |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514734/ https://www.ncbi.nlm.nih.gov/pubmed/34660592 http://dx.doi.org/10.3389/fcell.2021.735678 |
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